{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T03:10:33Z","timestamp":1721617833844},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Loss of CD26 surface expression on the circulating malignant T\u2010cell is the most widely accepted diagnostic marker in patients with leukemic cutaneous T\u2010cell lymphoma (CTCL). CTCL cases with reemergence of CD7 and\/or CD26 surface expression are unusual and of uncertain prognosis. We report the case of an erythrodermic leukemic mycosis fungoides patient who had achieved temporary remission after several months on multimodality immunotherapy and extracorporeal photopheresis, but who relapsed with aggressive disease phenotypically characterized by CD4+ T\u2010cells with high CD26 expression. Polymerase chain reaction studies and high\u2010throughput sequencing analyses from peripheral blood mononuclear cells at presentation and relapse consistently showed an identical clonal T\u2010cell receptor suggesting evolution of her original malignant clone which lacked CD26 expression. Interestingly, quantitative expression of the sialomucin, CD164, mirrored her clinical picture, thus favoring its reliability as a novel biomarker in CTCL.<\/jats:p>","DOI":"10.1111\/cup.12899","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T16:11:44Z","timestamp":1484323904000},"page":"462-466","source":"Crossref","is-referenced-by-count":2,"title":["Gain of CD26 expression on the malignant T\u2010cells in relapsed erythrodermic leukemic mycosis fungoides"],"prefix":"10.1111","volume":"44","author":[{"given":"Filiberto","family":"Cedeno\u2010Laurent","sequence":"first","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Wysocka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrom E.","family":"Obstfeld","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto A.","family":"Novoa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmela C.","family":"Vittorio","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Kai","family":"Weng","sequence":"additional","affiliation":[{"name":"Division of Blood and Marrow Transplantation, Department of Medicine Stanford University School of Medicine  Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain H.","family":"Rook","sequence":"additional","affiliation":[{"name":"Department of Dermatology Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.014"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.857"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.6.739"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/U1Y6-J4AG-5M4M-7AYV"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201748"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04014.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118538"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.279"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021726"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.356"},{"issue":"3","key":"e_1_2_5_12_1","first-page":"169","article-title":"Detection of clonal T\u2010cell receptor gamma gene rearrangements using fluorescent\u2010based PCR and automated high\u2010resolution capillary electrophoresis","volume":"6","author":"Luo V","year":"2001","journal-title":"Mol Diagn"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007420"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP1NA3YCHCDEIG"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.1.45"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/2008-7802.181759"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13645"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.200"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-06-2181"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-396457"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:21:30Z","timestamp":1696321290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,10]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/cup.12899"],"URL":"https:\/\/doi.org\/10.1111\/cup.12899","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,10]]}}}