{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:27Z","timestamp":1740124347771,"version":"3.37.3"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["U1165\u2010Paris","F\u201075010"],"award-info":[{"award-number":["U1165\u2010Paris","F\u201075010"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>A 62\u2010year\u2010old human immunodeficiency virus\u2010positive man was admitted for multiple cutaneous and subcutaneous nodules on his lower limbs, corresponding to an undifferentiated proliferation of spindle and pleomorphic cells, with irregular nuclei and numerous mitoses. The tumor cells were negative for a large panel of immunohistochemical markers, except CD10. MDM2 immunohistochemical staining was also negative, leading to the diagnosis of F\u00e9d\u00e9ration Nationale des Centres de Lutte contre le Cancer grade III undifferentiated pleomorphic sarcoma (UPS). Array\u2010comparative genomic hybridization showed a highly complex karyotype, with amplification of the 4q12 region, an area that contains only the platelet\u2010derived growth factor receptor \u03b1 (PDGFRa) gene. This amplification of PDFGRa, molecular hallmark of intimal sarcoma (IS), led to the diagnosis of skin IS metastasis. A positron emission tomography showed a hypermetabolic mass protruding in the preaortic area, consistent with the diagnosis of aortic IS. Our study shows that a rare differential diagnosis in peripheral UPS can be IS skin metastasis, and underlines the importance of molecular analyses in UPS.<\/jats:p>","DOI":"10.1111\/cup.12907","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T11:16:49Z","timestamp":1484911009000},"page":"477-479","source":"Crossref","is-referenced-by-count":2,"title":["PDGFRa amplification in multiple skin lesions of undifferentiated pleomorphic sarcoma: A clue for intimal sarcoma metastases"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0861-0594","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Osio","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9, UMR\u2010S 1165  Paris France"},{"name":"INSERM, U1165\u2010Paris  Paris France"},{"name":"Laboratoire de Pathologie H\u00f4pital Saint\u2010Louis AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Dominique","family":"Vignon\u2010Pennamen","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9, UMR\u2010S 1165  Paris France"},{"name":"INSERM, U1165\u2010Paris  Paris France"},{"name":"Laboratoire de Pathologie H\u00f4pital Saint\u2010Louis AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Pedeutour","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Centre Hospitalier Universitaire de Nice  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Le Maignan","sequence":"additional","affiliation":[{"name":"Service d'Oncologie M\u00e9dicale H\u00f4pital Saint\u2010Louis AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Koskas","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Vasculaire H\u00f4pital la Piti\u00e9 Salp\u00e9tri\u00e8re AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9l\u00e8ste","family":"Lebb\u00e9","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Saint\u2010Louis AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Janin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9, UMR\u2010S 1165  Paris France"},{"name":"INSERM, U1165\u2010Paris  Paris France"},{"name":"Laboratoire de Pathologie H\u00f4pital Saint\u2010Louis AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Battistella","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot Sorbonne Paris Cit\u00e9, UMR\u2010S 1165  Paris France"},{"name":"INSERM, U1165\u2010Paris  Paris France"},{"name":"Laboratoire de Pathologie H\u00f4pital Saint\u2010Louis AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"232","volume-title":"WHO Classification of Tumors of Soft Tissue and Bone","author":"Bode\u2010Lesniewska B","year":"2013"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828f51b9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1543"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20727"},{"issue":"4","key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/PAS.0000000000000184","article-title":"Intimal sarcoma is the most frequent primary cardiac sarcoma. Clinicopathologic and molecular retrospective analysis of 100 primary cardiac sarcoma","volume":"38","author":"Neuville A","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.01.014"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000159774.70288.7d"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.850560"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12907","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:22:00Z","timestamp":1696321320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/cup.12907"],"URL":"https:\/\/doi.org\/10.1111\/cup.12907","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2017,2,15]]}}}