{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:07:49Z","timestamp":1788260869147,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Intradepidermal proliferation of Merkel cells without any dermal component has been interpreted as either a hyperplastic process secondary to chronic ultraviolet radiation or a neoplastic process, namely Merkel cell carcinoma (<jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>) in situ. The recent criteria that have been proffered to diagnose <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> in situ, unfortunately, are identical to those that have been applied to Merkel cell hyperplasia in the past, posing a diagnostic quandary when faced with an intraepidermal proliferation of Merkel cells. Most previously reported cases of <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> in situ have occurred within associated epithelial lesion that includes solar (actinic) keratosis and squamous\u2010cell carcinoma in situ. Similarly, Merkel cell hyperplasia has been reported to occur in association with a variety of epithelial lesions as well as on chronically sun\u2010damaged skin. Herein, a case of an intraepidermal proliferation of Merkel cells within a seborrheic keratosis is presented accompanied by a discussion on whether the proliferation represents another case of Merkel cell carcinoma in situ or an incidental hyperplastic process on chronically sun\u2010damaged skin.<\/jats:p>","DOI":"10.1111\/cup.12908","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T11:16:04Z","timestamp":1484910964000},"page":"480-485","source":"Crossref","is-referenced-by-count":20,"title":["Intraepidermal proliferation of Merkel cells within a seborrheic keratosis: Merkel cell carcinoma in situ or Merkel cell hyperplasia?"],"prefix":"10.1111","volume":"44","author":[{"given":"Jeanne","family":"McFalls","sequence":"first","affiliation":[{"name":"Department of Dermatology Thomas Jefferson University  Philadelphia 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