{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:32:27Z","timestamp":1790397147098,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We have encountered cases of post\u2010radiation angiosarcoma (<jats:styled-content style=\"fixed-case\">PRAS<\/jats:styled-content>) histologically mimicking radiation dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of <jats:styled-content style=\"fixed-case\">PRAS<\/jats:styled-content> from institutional\/consultation archives from 2006 to 2016 were reviewed. For inclusion, tumors had to have inapparent\/subtle tumor at low magnification and scattered individual tumor cells resembling radiation fibroblasts. Prior ancillary studies were reviewed, with additional immunostains performed as needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>10 cases met criteria. All occurred in women treated for breast cancer (mean age 71 years). All had similar findings: in particular, scattered single atypical cells with pleomorphic nuclei associated with microscopic hemorrhage. They also had narrow, slightly wavy \u201cworm\u2010like\u201d vascular channels lined by atypical endothelial cells that lacked architectural complexity. Four cases showed focal areas of more conventional angiosarcoma. One case was an excision of a large mass that showed the \u201cradiation dermatitis\u2010like\u201d pattern radiating out from the central mass. All were positive for vascular markers (<jats:styled-content style=\"fixed-case\">CD31<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD34<\/jats:styled-content>, and\/or <jats:styled-content style=\"fixed-case\">ERG<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content> amplification was demonstrated by <jats:styled-content style=\"fixed-case\">FISH<\/jats:styled-content> in both cases tested. In 3 of 3 cases with available re\u2010excision specimens, more obvious angiosarcoma was seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\">PRAS<\/jats:styled-content> can be very subtle and histologically mimic radiation dermatitis. Careful attention to histologic features and ancillary tests allow accurate diagnosis in subtle <jats:styled-content style=\"fixed-case\">PRAS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12917","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T10:32:55Z","timestamp":1486463575000},"page":"456-461","source":"Crossref","is-referenced-by-count":15,"title":["Radiation\u2010associated angiosarcoma in the setting of breast cancer mimicking radiation dermatitis: A diagnostic pitfall"],"prefix":"10.1111","volume":"44","author":[{"given":"Brianne H.","family":"Daniels","sequence":"first","affiliation":[{"name":"Department of Pathology University of California San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Jordi","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinn","family":"Downs\u2010Kelly","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-5908","authenticated-orcid":false,"given":"Steven D.","family":"Billings","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(194805)1:1<64::AID-CNCR2820010105>3.0.CO;2-W"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126055.33916.0b"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000156664.04955.83"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02293.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.6.757"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.10.025"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.134"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01843.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20827"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090637"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.11.002"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000163572.18673.8d"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2009.10.001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198502000-00012"},{"key":"e_1_2_5_16_1","volume-title":"Weedon's Skin Pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31815bf8fe"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-015-3379-2"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:21:19Z","timestamp":1696321279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/cup.12917"],"URL":"https:\/\/doi.org\/10.1111\/cup.12917","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}