{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:43:00Z","timestamp":1791646980777,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009026","name":"Smith and Nephew","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dermatopathologists assess wounds secondary to trauma, infection, or oncologic resection that can be challenging to reconstruct. OASIS Ultra, an extracellular matrix, has been described for use in chronic and burn wounds. The aim of this pilot study is to assess wound healing in post\u2010traumatic and infective wounds treated with OASIS using histological markers of repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Adults with traumatic, infective or iatrogenic wound defects with size precluding primary closure were eligible. Half the wound was randomly assigned to receive OASIS plus standard therapy; the other half received standard of care (SOC) therapy. During dressing changes, standardized\u2010scale photographs were taken and biopsies obtained. Histologic sections were reviewed for degree of acute inflammation and extent of tissue repair. Neutrophils, edema, hemorrhage, necrosis, fibroblasts, collagen density and neovascularization were semi\u2010quantitatively assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four skin biopsies from 7 patients with 10 acute wounds met eligibility criteria. Histologically, OASIS samples demonstrated improved acute inflammation scores compared to SOC. No patients experienced OASIS\u2010related complications. OASIS\u2010treated wound halves trended toward more wound contraction and improved tissue repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our scoring system aids histopathological wound assessment. Treatment of critical\u2010sized, post\u2010traumatic, acute wounds with OASIS resulted in decreased inflammation, and potentially more advanced wound healing, compared to SOC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12925","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T04:36:37Z","timestamp":1488515797000},"page":"523-529","source":"Crossref","is-referenced-by-count":32,"title":["Histopathological assessment of OASIS Ultra on critical\u2010sized wound healing: a pilot study"],"prefix":"10.1111","volume":"44","author":[{"given":"Daniel Dante","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care Massachusetts General Hospital  Boston Massachusetts"},{"name":"Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4003-7193","authenticated-orcid":false,"given":"Rosalynn M.","family":"Nazarian","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts"},{"name":"Department of Pathology, Dermatopathology Unit Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Demetri","sequence":"additional","affiliation":[{"name":"Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomaz","family":"Mesar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care Massachusetts General Hospital  Boston Massachusetts"},{"name":"Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Dijkink","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care Massachusetts General 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