{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:14:31Z","timestamp":1766268871993,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Chronic lymphedema predisposes to develop malignant cutaneous tumors, including angiosarcoma, Kaposi's sarcoma and B\u2010cell lymphoma. T\u2010cell malignancy has rarely been associated with chronic lymph stasis. Here, we report a case of primary cutaneous anaplastic large cell lymphoma (<jats:styled-content style=\"fixed-case\">pcALCL<\/jats:styled-content>) with lymphatic spread associated with chronic lymphedema. The patient is a 56\u2010year\u2010old man who received orchiectomy and right inguinal lymphadenectomy for malignant seminoma 10\u2009years ago, which led to prominent lymphedema of the right leg. He developed extensive skin nodules on the lymphedematous area for 3\u2009months. Histopathology findings confirmed a diagnosis of <jats:styled-content style=\"fixed-case\">pcALCL<\/jats:styled-content>, which is a subtype of cutaneous T\u2010cell lymphoma characterized by the presence of <jats:styled-content style=\"fixed-case\">CD30<\/jats:styled-content>+ T cells. Intralymphatic infiltration of malignant cells is prominent. The pathogenesis of intralymphatic cutaneous anaplastic large cell lymphoma is largely unknown. Our case suggests that chronic lymphedema resulted in persistent <jats:styled-content style=\"fixed-case\">CD4<\/jats:styled-content>+ T\u2010cell inflammation, which then may contribute to the development of <jats:styled-content style=\"fixed-case\">pcALCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cup.12933","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T11:28:33Z","timestamp":1490354913000},"page":"616-619","source":"Crossref","is-referenced-by-count":5,"title":["Primary cutaneous anaplastic large cell lymphoma with intralymphatic involvement associated with chronic lymphedema"],"prefix":"10.1111","volume":"44","author":[{"given":"Peiyuan","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Nong","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingru","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall E.","family":"Kadin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Surgery Boston University School of Medicine  Providence Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University First Hospital  Beijing 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