{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:59:35Z","timestamp":1782493175579,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Syringocystadenocarcinoma papilliferum (<jats:styled-content style=\"fixed-case\">SCACP<\/jats:styled-content>) is an exceedingly rare cutaneous adnexal neoplasm. We aimed to investigate the clinicopathologic and immunophenotypic features of <jats:styled-content style=\"fixed-case\">SCACP<\/jats:styled-content>, and to discuss the prognosis of this rare entity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively collected clinical, pathological and follow\u2010up data of 10 cases with <jats:styled-content style=\"fixed-case\">SCACP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 8 males and 2 females, with ages ranging from 26 to 74\u2009years. The chest was most frequently involved. Histologically, 1 case only showed <jats:styled-content style=\"fixed-case\">SCACP<\/jats:styled-content> in situ, 9 cases presented with variable invasive components of adenocarcinoma and\/or squamous cell carcinoma in addition to areas of in situ. Apocrine differentiation with decapitation was evident in 4 cases and mucinous metaplasia was noted in 1 case. <jats:styled-content style=\"fixed-case\">P63<\/jats:styled-content> was positive in invasive squamous cell carcinoma, while <jats:styled-content style=\"fixed-case\">CK7<\/jats:styled-content> was variably positive in invasive adenocarcinoma. Regional lymph node metastasis was confirmed by pathological examination in 4 patients. Follow up was available for 9 patients, ranging from 3 to 112\u2009months. Three patients died of the disease within 1\u2009year after recurrences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Because of high rates of regional lymph node metastasis and mortality in our patients, clinical behavior of <jats:styled-content style=\"fixed-case\">SCACP<\/jats:styled-content> seems to be more aggressive than that previously reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12934","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T11:37:46Z","timestamp":1490355466000},"page":"538-543","source":"Crossref","is-referenced-by-count":31,"title":["Syringocystadenocarcinoma papilliferum: Clinicopathologic analysis of 10 cases"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-8269","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center  Shanghai People's Republic of China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Yi","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center  Shanghai People's Republic of China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center  Shanghai People's Republic of China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010Xia","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center  Shanghai People's Republic of China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Cheng","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pathology, First People's Hospital Shanghai Jiao Tong University  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1980.tb02939.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181b96c0c"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.t01-4-297345.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01403.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.5858\/2009-0399-CR.1","article-title":"Diagnostic pitfalls in syringocystadenocarcinoma papilliferum: case report and review of the literature","volume":"134","author":"Leeborg N","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01419.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182a38bb9"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318235dd34"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31826cffc6"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30023.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3180339528"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00363.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117723"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.4.762"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02421.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"22335","DOI":"10.5070\/D3204022335","article-title":"Syringocystadenocarcinoma papilliferum with locoregional metastases","volume":"20","author":"Satter E","year":"2014","journal-title":"Dermatol Online J"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000381940"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000370"},{"key":"e_1_2_5_20_1","first-page":"685","article-title":"Syringocytadenoma papilliferum with malignant evolution. 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