{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:24:54Z","timestamp":1789457094384,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:00:00Z","timestamp":1492473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>Adult\u2010onset Still disease (<jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>) is a rare autoinflammatory syndrome characterized by recurring fevers, arthralgia, and consistent laboratory abnormalities that include leukocytosis and hyperferritinemia. Skin findings accompany the disease in nearly 90% of the cases. Early reports described evanescent, pruritic, salmon\u2010pink or urticarial lesions, referred to as the typical eruption of <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>. Histopathologic findings consist of superficial perivascular dermatitis with varying number of interstitial neutrophils. Later reports described a more persistent rash that tended to be photodistributed, hyperpigmented, often in a linear configuration, sometimes in a rippled pattern, referred to as the atypical eruption of <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>. The presence of individual necrotic keratinocytes in the upper spinous layer has been the consistent histopathologic finding. The persistent rash may not represent an atypical presentation of <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content> as recent reports indicate a high prevalence of the rash. Emerging data also suggest that patients with persistent eruption have a worse prognosis. The recognition of the clinical and histopathological findings of skin eruptions of <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content> may facilitate an earlier diagnosis, potentially improving disease outcome. Herein, clinical and histopathological features of cutaneous manifestation of <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content> in 2 Asian women are highlighted accompanied by a relevant review of the disease.<\/jats:p>","DOI":"10.1111\/cup.12935","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T10:51:34Z","timestamp":1490439094000},"page":"591-595","source":"Crossref","is-referenced-by-count":25,"title":["Clinical and histopathological features of cutaneous manifestations of adult\u2010onset Still disease"],"prefix":"10.1111","volume":"44","author":[{"given":"Erin","family":"Santa","sequence":"first","affiliation":[{"name":"Bryn Mawr Dermatology (private practice)  Villanova Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M.","family":"McFalls","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joya","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Sidney Kimmel Medical College at Thomas Jefferson University  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-2719","authenticated-orcid":false,"given":"Jason B.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Sidney Kimmel Medical College at Thomas Jefferson University  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2014.971052"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247150"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.02.032"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.30.2.121"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199103000-00004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000021"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.05.003"},{"key":"e_1_2_5_9_1","first-page":"424","article-title":"Preliminary criteria for classification of adult Still's disease","volume":"19","author":"Yamaguchi M","year":"1992","journal-title":"J Rheumatol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200205000-00003"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2487-4"},{"key":"e_1_2_5_12_1","first-page":"33","article-title":"Treatment of adult\u2010onset Still's disease: a review","volume":"11","author":"Jamilloux Y","year":"2014","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2614-2"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPZE77UAPSMDCD"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01570.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12426"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2012.01549.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3180332826"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31820c6dd1"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.04.063"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:13:09Z","timestamp":1695471189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,18]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/cup.12935"],"URL":"https:\/\/doi.org\/10.1111\/cup.12935","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,18]]}}}