{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:58:24Z","timestamp":1793764704547,"version":"4.6.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T00:00:00Z","timestamp":1494892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Charles University Research Fund","award":["SVV-2017-No. 260 391"],"award-info":[{"award-number":["SVV-2017-No. 260 391"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The so\u2010called acquired elastotic hemangioma (<jats:styled-content style=\"fixed-case\">AEH<\/jats:styled-content>) represents a peculiar vascular lesion affecting the sun\u2010damaged skin of the extensor surface of the forearms or the lateral aspect of the neck of middle\u2010aged or elderly women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a clinicopathological and immunohistochemical study of a series of 6 lesions located on the knee or elbow showing epithelial features of lichen simplex chronicus (<jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content>)\/prurigo nodularis (<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>) with a marked subepidermal vascular proliferation closely resembling <jats:styled-content style=\"fixed-case\">AEH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Microscopically, all cases of cutaneous lesions showed epithelial features of <jats:styled-content style=\"fixed-case\">LSC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>, that is compact hyperkeratosis with focal parakeratosis, irregular acanthosis, prominent hypergranulosis. Moreover, a marked subepidermal vascular proliferation arranged in a horizontal band closely resembling <jats:styled-content style=\"fixed-case\">AEH<\/jats:styled-content> was detected in these lesions. Another common histopathological finding was eccrine duct squamous metaplasia and\/or hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While <jats:styled-content style=\"fixed-case\">AEH<\/jats:styled-content> represents a distinctive clinicopathological variant of hemangioma characteristically appearing on sun\u2010exposed areas of middle\u2010aged or elderly patients, the herein described lesions seem to be non\u2010neoplastic epithelial, vascular and eccrine sweat duct reactive changes which are likely to be associated with chronic pressure or repeated mechanical stimulation with a marked predilection for the knee and elbow.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12945","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T15:48:19Z","timestamp":1491407299000},"page":"605-611","source":"Crossref","is-referenced-by-count":11,"title":["Acquired elastotic hemangioma\u2010like changes and eccrine sweat duct squamous metaplasia in lichen simplex chronicus\/prurigo nodularis\u2010like lesions of the knee and elbow"],"prefix":"10.1111","volume":"44","author":[{"given":"Denisa","family":"Kacerovska","sequence":"first","affiliation":[{"name":"Sikl's Department of Pathology Charles University in Prague, Medical Faculty in Pilsen  Pilsen Czech Republic"},{"name":"Bioptical Laboratory  Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Portelli","sequence":"additional","affiliation":[{"name":"Department for Health Promotion and Mother and Child's Care G. 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