{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:18:12Z","timestamp":1789697892714,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Desmoplastic melanoma (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) and cutaneous malignant peripheral nerve sheath tumors (<jats:styled-content style=\"fixed-case\">MPNST<\/jats:styled-content>) reveal histological and immunohistochemical similarities, including <jats:styled-content style=\"fixed-case\">S100<\/jats:styled-content> positivity and negative staining for conventional melanocytic markers. We present 3 cases of cutaneous <jats:styled-content style=\"fixed-case\">S100<\/jats:styled-content>\u2010positive spindle cell tumors in elderly patients, in which first findings led to initial misdiagnoses as cutaneous <jats:styled-content style=\"fixed-case\">MPNST<\/jats:styled-content> and benign peripheral sheath nerve tumor (neurofibroma). The identification of adjacent atypical melanocytic hyperplasia in the overlying skin along with tumor cell proliferation, also in the superficial dermis, the neurotropic component and the absence of any relationship between the tumor and a major nerve, pre\u2010existing neural benign tumor or the existence of stigmata suggestive of neurofibromatosis raised consideration of a DM. Careful attention should be paid to the presence of a firm dermal nodule and atypical scar lesions especially in sun\u2010exposed areas (mainly head and neck region) in elderly patients associated with <jats:styled-content style=\"fixed-case\">S100<\/jats:styled-content>\u2010positive spindle cell proliferation, solar elastosis and adjacent atypical melanocytic proliferation. In such cases, the possibility of a <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> should be excluded with caution, especially if the tumor reveals a paucicellular morphology resembling various non\u2010melanocytic neoplasms including malignant or benign peripheral sheath nerve tumors.<\/jats:p>","DOI":"10.1111\/cup.12949","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T17:14:51Z","timestamp":1492017291000},"page":"632-638","source":"Crossref","is-referenced-by-count":14,"title":["Desmoplastic melanoma may mimic a cutaneous peripheral nerve sheath tumor: Report of 3 challenging cases"],"prefix":"10.1111","volume":"44","author":[{"given":"Isidro","family":"Machado","sequence":"first","affiliation":[{"name":"Department of Pathology Instituto Valenciano de Oncolog\u00eda  Valencia 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