{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:54:05Z","timestamp":1772142845115,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NCI Cancer Center","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Well\u2010differentiated neuroendocrine tumors (WDNETs) in skin include metastases from visceral primary sites and very uncommonly, primary cutaneous carcinoid tumors. Cutaneous WDNET may present a diagnostic challenge and in particular can be mistaken for a benign skin adnexal tumor. In contrast to cutaneous adnexal tumors, metastatic adenocarcinomas to the skin are cytokeratin 5\/6 (CK5\/6) and p63 negative in the majority of cases. It is unclear if failure to stain with CK5\/6 and p63 would be helpful in differentiating WDNETs from cutaneous adnexal neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 10 cases of cutaneous WDNETs (8 cases of metastatic disease and 2 presumed primary carcinoid tumors of the skin) and performed immunohistochemical stains for CK5\/6 and p63 on all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 10 cases were negative with both CK5\/6 and p63.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Negative staining for CK5\/6 and p63 can be helpful to distinguish WDNETs from cutaneous adnexal neoplasms. It is important to consider WDNETs in the differential diagnosis of cutaneous adnexal neoplasms as low\u2010grade tumors may be the first sign of aggressive metastatic disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12952","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T04:27:02Z","timestamp":1492489622000},"page":"557-562","source":"Crossref","is-referenced-by-count":7,"title":["Well\u2010differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5\/6 and p63"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3490","authenticated-orcid":false,"given":"Gauri","family":"Panse","sequence":"first","affiliation":[{"name":"Department of Dermatology, Division of Dermatopathology Yale School of Medicine  New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn E.","family":"Cowper","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Dermatopathology Yale School of Medicine  New Haven Connecticut"},{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Leffell","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Dermatopathology Yale School of Medicine  New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Pulitzer","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine J.","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Dermatopathology Yale School of Medicine  New Haven Connecticut"},{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ec124e"},{"key":"e_1_2_6_3_1","volume-title":"WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart","author":"Travis WD","year":"2015"},{"key":"e_1_2_6_4_1","first-page":"113","article-title":"Biology and treatment of metastatic gastrointestinal neuroendocrine tumors","volume":"2","author":"Strosberg JR","year":"2008","journal-title":"Gastrointest Cancer 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