{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:06:13Z","timestamp":1789686373242,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Polarizable calcium oxalate (<jats:styled-content style=\"fixed-case\">CaOx<\/jats:styled-content>) crystals have been well documented in breast biopsies, generally associated with benign apocrine metaplasia. In contrast, polarizable crystals are only rarely reported in skin adnexal neoplasms. We report 3 different cases of sweat gland tumors with polarizable crystals morphologically suggestive of <jats:styled-content style=\"fixed-case\">CaOx<\/jats:styled-content>: 1 apocrine hidrocystoma and 2 tubular apocrine adenomas. The histologic features were examined in 3 cases. Clinical presentation summary included 2 males and 1 female, ages 53 to 74 years, with lesions located on the left cheek, inferior vertex scalp and the left eyebrow. All 3 cases showed polarizable, geometric, plate\u2010like and fractured, colorless crystals within the lumens of the neoplasm. Of note, these crystals were seen only on the toluidine blue\u2010stained section of Case #1, but were not present on the corresponding permanent section. We hypothesize that polarizable crystals may be present in sweat gland neoplasms more often than previously documented, but that they may often dissolve with routine processing, accounting for their rare visibility. We highlight this rare finding, and suggest that it may be underreported. We only noted this finding in benign apocrine tumors; further investigation would be necessary to determine whether these crystals are also seen in other cutaneous adnexal neoplasms.<\/jats:p>","DOI":"10.1111\/cup.12962","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T06:46:03Z","timestamp":1494571563000},"page":"698-702","source":"Crossref","is-referenced-by-count":4,"title":["Polarizable crystals in apocrine sweat gland tumors: A series of 3 cases"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9824-1616","authenticated-orcid":false,"given":"Gina","family":"Johnson","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Science, Department of Pathology  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7397-2159","authenticated-orcid":false,"given":"Jerad M.","family":"Gardner","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Science, Department of Pathology  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-3783","authenticated-orcid":false,"given":"Sara C.","family":"Shalin","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Science, Department of Pathology  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,13]]},"reference":[{"issue":"3","key":"e_1_2_4_2_1","first-page":"149","article-title":"Oxalate nephrosis and crystalline myocarditis. 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The role of oxalate crystal deposition in renal tubules","volume":"33","author":"Ono K","year":"1987","journal-title":"ASAIO Trans"},{"issue":"5","key":"e_1_2_4_10_1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.5858\/2000-124-0774-SMTDUC","article-title":"Staining method to demonstrate urate crystals in formalin\u2010fixed, paraffin\u2010embedded tissue sections","volume":"124","author":"Shidham V","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000204"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70133-3"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.03965.x"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.9.800"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12962","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:17:36Z","timestamp":1695536256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,13]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/cup.12962"],"URL":"https:\/\/doi.org\/10.1111\/cup.12962","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,13]]}}}