{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:01:04Z","timestamp":1793397664897,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T00:00:00Z","timestamp":1497312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Merkel cell carcinoma (<jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>) is a rare but aggressive cutaneous carcinoma. <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> typically involves dermis and although epidermotropism has been reported, <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> strictly intraepidermal or in situ (<jats:styled-content style=\"fixed-case\">MCCIS<\/jats:styled-content>) is exceedingly rare. Most of the cases of <jats:styled-content style=\"fixed-case\">MCCIS<\/jats:styled-content> described so far have other associated lesions, such as squamous or basal cell carcinoma, actinic keratosis and so on. Herein, we describe 3 patients with <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> strictly in situ, without a dermal component.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our patients were elderly. 2 of the lesions involved the head and neck area and 1 was on a finger. All tumors were strictly intraepidermal in the diagnostic biopsies, and had histomorphologic features and an immunohistochemical profile supporting the diagnosis of <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>. Excisional biopsies were performed in 2 cases and failed to reveal dermal involvement by <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> or other associated malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusion<\/jats:title><jats:p>Our findings raise the awareness that <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content> strictly in situ does exist and it should be included in the differential diagnosis of Paget's or extramammary Paget's disease, pagetoid squamous cell carcinoma, melanoma and other neoplasms that typically show histologically pagetoid extension of neoplastic cells. Considering the limited number of cases reported to date, the diagnosis of isolated <jats:styled-content style=\"fixed-case\">MCCIS<\/jats:styled-content> should not warrant a change in management from the typical <jats:styled-content style=\"fixed-case\">MCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12966","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T00:38:33Z","timestamp":1495586313000},"page":"684-691","source":"Crossref","is-referenced-by-count":40,"title":["Intraepidermal Merkel cell carcinoma: A case series of a rare entity with clinical follow up"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-8966","authenticated-orcid":false,"given":"George","family":"Jour","sequence":"first","affiliation":[{"name":"Department of Pathology, Dermatopathology Section The University of Texas MD, Anderson Cancer Center  Houston 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