{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:36:27Z","timestamp":1782426987871,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Amschwand Sarcoma Center Foundation and Maynard Family"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Cutaneous angiosarcoma can be challenging to diagnose particularly when poorly vasoformative and studied on biopsies. We report a case of a cutaneous angiosarcoma with strong positivity for tyrosinase, the first to our knowledge, initially misdiagnosed as melanoma. We subsequently evaluated the reactivity of panmelanocytic cocktail (tyrosinase, <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\u201045 and Melan\u2010A), <jats:styled-content style=\"fixed-case\">SOX10<\/jats:styled-content>, tyrosinase and <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content> in a large tissue microarray (<jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content>) of angiosarcoma. The <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content> included 142 cases of angiosarcomas (29 cutaneous, 22 primary breast, 41 post\u2010radiation breast, 15 visceral, 26 deep soft tissue and bone, 5 chronic lymphedema\u2010associated and 4 angiosarcomas arising in other sarcomas). Immunohistochemical studies were performed with anti\u2010panmelanocytic cocktail, <jats:styled-content style=\"fixed-case\">anti\u2010SOX10<\/jats:styled-content>, anti\u2010<jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content> and anti\u2010tyrosinase antibodies. <jats:styled-content style=\"fixed-case\">TMA<\/jats:styled-content> staining results were scored on intensity and percentage of tumoral labeling. Aside from the index case, no cases (0 of 133) showed positivity for tyrosinase including 28 cutaneous angiosarcomas. One breast angiosarcoma (1 of 131) was positive for <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>. All cases were negative for <jats:styled-content style=\"fixed-case\">SOX10<\/jats:styled-content> and panmelanocytic cocktail (0 of 132). Angiosarcomas can rarely be positive for tyrosinase and <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>. Pathologists should be cognizant of these rare exceptions to prevent confusion with melanoma. Additional immunohistochemical markers for vascular and melanocytic differentiation, thorough histological examination for vasoformative and in situ areas as well as clinical impression are helpful in these exceptionally problematic cases.<\/jats:p>","DOI":"10.1111\/cup.12968","type":"journal-article","created":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T05:02:43Z","timestamp":1495861363000},"page":"692-697","source":"Crossref","is-referenced-by-count":6,"title":["Index report of cutaneous angiosarcomas with strong positivity for tyrosinase mimicking melanoma with further evaluation of melanocytic markers in a large angiosarcoma series"],"prefix":"10.1111","volume":"44","author":[{"given":"Alicia","family":"Leon\u2010Castillo","sequence":"first","affiliation":[{"name":"Pathology Service Hospital Universitario Marques de Valdecilla  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7138-0923","authenticated-orcid":false,"given":"John S. 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