{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:26:30Z","timestamp":1778689590732,"version":"3.51.4"},"reference-count":8,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Friend leukemia integration site 1 (<jats:italic><jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content>\u20101<\/jats:italic>) nuclear transcription factor has been proposed as a suitable tool in the differential diagnosis of small round cell sarcomas. It has also been described as a nuclear marker of endothelial differentiation. Expression of <jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content>\u20101 has been demonstrated in Ewing's sarcoma\/primitive neuroectodermal tumor (<jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content>) and vascular neoplasms. In the present study, we describe 2 cases of metastatic melanoma with small round blue cell morphology that showed strong nuclear expression of <jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content>\u20101. Because of the small round blue cell morphology and negative immunohistochemical staining for pan\u2010melanocytic cocktail (<jats:styled-content style=\"fixed-case\">HMB45<\/jats:styled-content>, anti <jats:styled-content style=\"fixed-case\">MART1<\/jats:styled-content> and anti\u2010tyrosinase) and <jats:styled-content style=\"fixed-case\">SOX10<\/jats:styled-content> in both cases, <jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content>\u20101 immunostaining was requested as part of the tumors workup. Ultimately, both cases were established as being metastatic melanoma. Dermatopathologists should be aware that melanoma can be strongly positive for <jats:styled-content style=\"fixed-case\">FLI<\/jats:styled-content>\u20101 and not misinterpret these cases for <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> or vascular lesions, especially when melanomas show unusual morphology.<\/jats:p>","DOI":"10.1111\/cup.12979","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T14:36:39Z","timestamp":1497278199000},"page":"790-793","source":"Crossref","is-referenced-by-count":6,"title":["Aberrant expression of <scp>FLI<\/scp>\u20101 in melanoma"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1787-9587","authenticated-orcid":false,"given":"Nisha","family":"Ramani","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Pathology SUNY Upstate Medical University  Syracuse New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyu P.","family":"Aung","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Jen","family":"Hwu","sequence":"additional","affiliation":[{"name":"Department Melanoma Medical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyadharsini","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Tetzlaff","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnathan L.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doina","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor G.","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Torres\u2010Cabala","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Dermatology The University of Texas MD Anderson Cancer Center  Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"216","article-title":"Immunohistochemistry of small round\u2010cell tumors","volume":"17","author":"Devoe K","year":"2000","journal-title":"Semin Diagn 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