{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:26:38Z","timestamp":1774139198464,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["ST.B130.16.049"],"award-info":[{"award-number":["ST.B130.16.049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Polo\u2010like kinase\u20101 (<jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101) is one of the key regulators of cell cycle progression. Increased expression of <jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 was observed in several tumor types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We immunohistochemically assessed <jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 expression in neoplastic and stromal compartments of 96 cutaneous melanomas, and analyzed associations between <jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 expression and clinicopathological characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 expression in cancer cells was not associated with basic clinical (eg, age, gender and tumor location) or histopathological (eg, Breslow thickness, mitotic rate and ulceration) parameters. However, increased <jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 was more frequent in tumors with concurrent regional nodal metastases and positive sentinel lymph node biopsy status. All primary tumors associated with co\u2010existing distant metastases exhibited high <jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 expression in melanoma cells. Conversely, <jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 expression in stromal cells was more frequent in tumors without nodal metastases. <jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 expression in both compartments was not associated with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PLK<\/jats:styled-content>\u20101 expression is associated with metastatic potential in cutaneous melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12985","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T07:02:38Z","timestamp":1497855758000},"page":"819-826","source":"Crossref","is-referenced-by-count":5,"title":["Polo\u2010like kinase\u20101 immunoreactivity is associated with metastases in cutaneous melanoma"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-9952","authenticated-orcid":false,"given":"Maciej","family":"Kaczorowski","sequence":"first","affiliation":[{"name":"Department of Pathomorphology and Oncological Cytology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Borowiec","sequence":"additional","affiliation":[{"name":"Department of Oncology and Division of Surgical Oncology Wroclaw Medical University  Wroclaw Poland"},{"name":"Lower Silesian Oncology Centre  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Donizy","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology and Oncological Cytology Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Pagacz","sequence":"additional","affiliation":[{"name":"Department 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