{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:25:57Z","timestamp":1777613157416,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intraepidermal acantholysis is a characteristic histopathological feature of pemphigus. The histopathology of scalp biopsies in pemphigus has not been widely discussed in the literature, although the scalp is commonly involved in pemphigus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 32 consecutive patients with scalp involvement (17 with pemphigus vulgaris [PV] and 15 with pemphigus foliaceus [PF]) were enrolled into the study. The histopathological examination of scalp biopsies was performed in all patients. Tissue specimens were stained with hematoxylin and eosin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acantholysis extended down the entire length of the outer root sheath of the hair follicle in 12 of 17 (70.6%) patients with PV. Follicular acantholysis in PF was restricted to the infundibulum and occurred in 12 of 15 (80.0%) patients. Acantholysis in the vellus hair follicles was observed in 12 of 17 (70.6%) and 9 of 15 (60.0%) cases, respectively. The miniaturization of sebaceous glands was seen in 14 of 17 (82.4%) and 12 of 15 (80.0%) patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Follicular acantholysis is a common histopathological feature of pemphigus. It may serve as a clue to the diagnosis of pemphigus subtypes, as PV and PF differ in the depth of follicular acantholysis. The miniaturization of sebaceous glands is a common histopathological feature observed in scalp specimens of patients with pemphigus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12994","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T17:30:44Z","timestamp":1497979844000},"page":"835-842","source":"Crossref","is-referenced-by-count":10,"title":["Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-0840","authenticated-orcid":false,"given":"Marta","family":"Sar\u2010Pomian","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Czuwara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Warsaw  Warsaw 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