{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:11:14Z","timestamp":1773040274468,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:00:00Z","timestamp":1500422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Primary cutaneous aggressive cytotoxic epidermotropic <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ T\u2010cell lymphoma is an extremely rare, rapidly progressing, cutaneous lymphoma, with frequent systemic involvement and poor prognosis, that still represents a diagnostic and therapeutic challenge, especially in the early stage. Herein, we report a case of an elderly woman with a fulminant course, who at onset presented with clinical and pathological features mimicking erythema multiforme (EM) and treated with cyclosporine that led to rapid deterioration with fatal outcome 6 months after disease onset. Histopathology showed a lichenoid, epidermotropic and nodular, angiocentric, dermal and subcutaneous infiltrate of <jats:styled-content style=\"fixed-case\">sF1<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+, <jats:styled-content style=\"fixed-case\">CD45RA<\/jats:styled-content>+ small to medium\u2010sized atypical lymphoid cells, which strongly expressed cytotoxic markers. Monoclonal T\u2010cell\u2010\u03b3 receptor was clonally rearranged and array\u2010<jats:styled-content style=\"fixed-case\">CGH<\/jats:styled-content> showed numerous chromosomal imbalances. This case evidences the clinical, pathological and therapeutic challenges involved in this tumor. The first biopsy showed an interface dermatitis\u2010like pattern, revealing the deceptive features that early cutaneous infiltrates of this aggressive lymphoma may have. A high suspicion for aggressive <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> and a low threshold for repeat biopsies should be maintained when faced with rapidly progressing and\/or ulcerative EM\u2010like lesions, especially if immunomodulatory therapy is being considered.<\/jats:p>","DOI":"10.1111\/cup.12995","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T12:32:41Z","timestamp":1498221161000},"page":"867-873","source":"Crossref","is-referenced-by-count":14,"title":["Erythema multiforme\u2010like lesions in primary cutaneous aggressive cytotoxic epidermotropic <scp>CD8<\/scp>+ T\u2010cell lymphoma: A diagnostic and therapeutic challenge"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8383-3443","authenticated-orcid":false,"given":"Carlo","family":"Tomasini","sequence":"first","affiliation":[{"name":"Department of Clinical\u2010Surgical, Diagnostic and Pediatric Sciences Dermatology Clinic University of Pavia, IRCCS Fondazione Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Novelli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Dermatology University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Fanoni","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio F.","family":"Berti","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65144-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12371"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-007-0033-z"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.07.043"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2155"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.022"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.119"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03172.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.2.199"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290804.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106005457"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00147.x"},{"issue":"3","key":"e_1_2_5_15_1","first-page":"11","article-title":"Primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma with a chronic and indolent course. 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