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We describe a unique case of subcutaneous metastasis of sarcomatoid renal cell carcinoma which was the first manifestation of the occult malignancy. The patient had a history of lipomas and dysplastic nevi and presented with an upper back mass. The mass, located superficially within the subcutis, was composed of atypical spindle cells arranged in a storiform pattern. By immunohistochemistry, the tumor cells were strongly diffusely positive for cytokeratin AE1\/AE3 and vimentin and negative for Melan\u2010A, S\u2010100 protein, SOX10, melanoma cocktail, epithelial membrane antigen (EMA), p63, CK7, CK18, CK20, smooth muscle actin (SMA), desmin, CD34, TTF\u20101, CD21, CD99 and bcl\u20102. Scattered tumor cells were positive for MDM2 immunostain, but MDM2 amplification was not detected using fluorescent in situ hybridization (FISH). Co\u2010expression of cytokeratin and vimentin by the tumor raised the possibility of metastatic renal cell carcinoma and positivity of the tumor for PAX8 supported this hypothesis. A large renal mass was detected radiologically and the subsequent nephrectomy specimen showed high\u2010grade clear cell renal cell carcinoma with sarcomatoid features.<\/jats:p>","DOI":"10.1111\/cup.12998","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T13:33:35Z","timestamp":1499175215000},"page":"874-877","source":"Crossref","is-referenced-by-count":5,"title":["Metastatic sarcomatoid renal cell carcinoma manifesting as a subcutaneous soft tissue mass"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6561-9806","authenticated-orcid":false,"given":"Valentina","family":"Logunova","sequence":"first","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olayemi","family":"Sokumbi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Section of Dermatopathology Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Iczkowski","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050606"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-000-0526-7"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23151"},{"key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0972-3919.84608","article-title":"Subcutaneous fatty tissue metastasis from renal cell carcinoma detected with fluorine\u201018 fluorodeoxyglucose positron emission tomography\/computed tomography and magnetic resonance imaging","volume":"26","author":"Tato\u011flu MT","year":"2011","journal-title":"Indian J Nucl Med"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0227"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01578.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0072-OA"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181d712ef"},{"issue":"8","key":"e_1_2_4_10_1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.5858\/2009-0373-OA.1","article-title":"PAX\u20102 is a helpful marker for diagnosing metastatic renal cell carcinoma: comparison with the renal cell carcinoma marker antigen and kidney\u2010specific cadherin","volume":"134","author":"Ozcan A","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.3"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.88"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.12.012"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200112000-00003"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pai.0000213144.70148.8e"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64038-2"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1309\/8VAV-J2FU-8CU9-EK18"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.5858\/2006-130-823-EORCCM"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10433.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T06:52:45Z","timestamp":1719298365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,24]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/cup.12998"],"URL":"https:\/\/doi.org\/10.1111\/cup.12998","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,24]]}}}