{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:33Z","timestamp":1740124353239,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371728"],"award-info":[{"award-number":["81371728"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Familial progressive hyperpigmentation (<jats:styled-content style=\"fixed-case\">FPH<\/jats:styled-content>) is an autosomal dominant genodermatosis characterized by hyperpigmented patches that increase in size and number with age. Since its initial description in an African\u2013American family in 1971, only a few cases of <jats:styled-content style=\"fixed-case\">FPH<\/jats:styled-content> have been documented. A three\u2010generation family with <jats:styled-content style=\"fixed-case\">FPH<\/jats:styled-content> in central China has also been reported. Here, we resurveyed that Chinese <jats:styled-content style=\"fixed-case\">FPH<\/jats:styled-content> family for a few unusual features including delayed age of onset and noninvolvement of ocular and oral mucosae. Electron microscopic examination of skin from the proband of the family showed that there were more melanosomes in lesional keratinocytes than in perilesional keratinocytes. Additionally, a large number of nonmembrane\u2010bound melanosome complexes were observed in the keratinocytes of hyperpigmented areas, whereas all of the melanosomes were dispersed in the keratinocytes of normally pigmented areas.<\/jats:p>","DOI":"10.1111\/cup.13012","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T14:16:52Z","timestamp":1501165012000},"page":"948-950","source":"Crossref","is-referenced-by-count":1,"title":["Familial progressive hyperpigmentation: A family resurvey and ultrastructural skin investigation"],"prefix":"10.1111","volume":"44","author":[{"given":"Tingmei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyun","family":"She","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-511X","authenticated-orcid":false,"given":"Yunhua","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,4]]},"reference":[{"issue":"6","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1001\/archderm.1971.04000180007002","article-title":"Familial progressive hyperpigmentation","volume":"103","author":"Chernosky ME","year":"1971","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb14812.x"},{"issue":"3","key":"e_1_2_5_4_1","first-page":"246","article-title":"Linkage of a locus determining familial progressive hyperpigmentation (FPH) to 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