{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:55:50Z","timestamp":1790286950960,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Immune checkpoint agents targeting programmed cell death\u20101 protein (<jats:styled-content style=\"fixed-case\">PD1<\/jats:styled-content>) or cytotoxic T\u2010lymphocyte\u2010associated protein\u20104 (<jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104) receptors are increasingly utilized in treatment of advanced malignancies. However, these immunotherapies are commonly associated with idiosyncratic cutaneous adverse reactions. Thus, recognition and awareness of these reactions are necessary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the skin biopsies of all patients on anti\u2010<jats:styled-content style=\"fixed-case\">PD1<\/jats:styled-content> therapy with or without ipilimumab who developed lichenoid inflammation and included those with microscopic suprabasal or intraepidermal clefts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four patients presented with interface dermatitis with microscopic intraepidermal clefts. In 2 patients, the clefts were well developed and had some acantholytic cells while the other 2 appeared to be spongiosis or inflammation related. Immunofluorescence was negative in 1 patient. None of them had clinical findings in keeping with paraneoplastic pemphigus (PP) and the symptoms improved with either topical corticosteroid or withdrawal of immunotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lichenoid drug reaction occurring in patients receiving anti\u2010<jats:styled-content style=\"fixed-case\">PD1<\/jats:styled-content> therapy may be associated with microscopic suprabasal or intraepidermal clefting. The clinical course was similar to lichenoid drug reactions without clefting even though some lesions may resemble PP microscopically.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13013","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T13:12:42Z","timestamp":1501247562000},"page":"851-856","source":"Crossref","is-referenced-by-count":25,"title":["PD\u20101 inhibitor\u2010associated lichenoid inflammation with incidental suprabasilar acantholysis or vesiculation\u2014Report of 4 cases"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-054X","authenticated-orcid":false,"given":"Shaun","family":"Chou","sequence":"first","affiliation":[{"name":"Tissue Pathology and Diagnostic Oncology Westmead Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Westmead Hospital  Sydney Australia"},{"name":"Sydney Medical School University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley Ji Eun","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Westmead Hospital  Sydney Australia"},{"name":"Sydney Medical School University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Fernandez\u2010Penas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Westmead Hospital  Sydney Australia"},{"name":"Sydney Medical School University of Sydney  Sydney 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