{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:06:15Z","timestamp":1777086375125,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chromoblastomycosis is a deep fungal infection characterized by a complex cellular granuloma. The aim of this study was to analyze the arrangement of cells responsible for the granuloma configuration of this disease by semiquantification of the cellular components of chromoblastomycosis skin biopsies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cells of cutaneous biopsies slides from 100 patients with untreated chromoblastomycosis were stained with hematoxylin\u2010eosin and the granuloma cells were evaluated by microscopic examination of the elements of each granuloma and semiquantified the number of cells through its expressivity in crosses and the histopathological variables. Their presence were coded in degrees of intensity and classified in two categories: low expression and high expression. The cells that constituted the granulomas were separated into three groups: A, B and C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The chromoblastomycotic granuloma analyzed by this semiquantification of its cellular components showed that there was high expression of the elements setting up a mixed organized mycotic granuloma. It was observed that mononuclear phagocytic system (A), polymorphonuclear phagocytic system (B) and lymphoplasmocytic infiltrate (C) were located around the fungus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results indicated that the granuloma present in the cutaneous lesion of chromoblastomycosis is a mixed organized mycotic granuloma with high expression of the cellular components.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13014","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T14:18:52Z","timestamp":1501251532000},"page":"915-918","source":"Crossref","is-referenced-by-count":7,"title":["Study on the organization of cellular elements in the granulomatous lesion caused by chromoblastomycosis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1451-0461","authenticated-orcid":false,"given":"Renan","family":"Minotto","sequence":"first","affiliation":[{"name":"Dermatology Service Santa Casa de Miseric\u00f3rdia de Porto Alegre Complexo Hospitalar  Porto Alegre Brazil"},{"name":"Graduate Program in Medicine: Department of Medical Sciences Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Albano Edelweiss","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicine: Department of Medical Sciences Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Department of Pathology, Faculdade de Medicina Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L\u00facia","family":"Scroferneker","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicine: Department of Medical Sciences Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Department of Microbiology, Immunology and Parasitology Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.112220"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20165142"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80250-5"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01608337"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802538001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2016.05.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-014-9824-7"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-015-9887-0"},{"key":"e_1_2_5_10_1","first-page":"190","volume-title":"Anatomia Patol\u00f3gica da Dermatite Verrucosa Cromomic\u00f3tica","author":"Tibiri\u00e7\u00e1 PQT","year":"1939"},{"key":"e_1_2_5_11_1","unstructured":"AzulayRD. 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