{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:04:15Z","timestamp":1781309055171,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Indeterminate dendritic cell neoplasm (<jats:styled-content style=\"fixed-case\">IDCN<\/jats:styled-content>) is an exceedingly rare and mostly cutaneous histiocytosis, frequently associated with other hematopoietic malignancies. We report 2 cases of multilesional cutaneous <jats:styled-content style=\"fixed-case\">IDCN<\/jats:styled-content>. A 55\u2010year\u2010old male with no associated malignancy and complete response to ultraviolet phototherapy; and a 72\u2010year\u2010old male with chronic myelomonocytic leukemia (<jats:styled-content style=\"fixed-case\">CMML<\/jats:styled-content>). Both cases showed histiocytoid cytology, positivity for <jats:styled-content style=\"fixed-case\">CD1a<\/jats:styled-content> and no expression of langerin or <jats:styled-content style=\"fixed-case\">BRAF<jats:sup>V600E<\/jats:sup><\/jats:styled-content>. With our patients, the literature describes 79 cases of <jats:styled-content style=\"fixed-case\">IDCNs<\/jats:styled-content>, including 65 (82%) with only skin involvement, 7 cases (9%) with involvement of skin and a second site, 5 cases (6%) involving lymph nodes only, 1 splenic lesion and 1 systemic disease. Seventeen cases (22%) were associated with other hematopoietic malignancies, most commonly <jats:styled-content style=\"fixed-case\">CMML<\/jats:styled-content> (6 cases), follicular lymphoma (4 cases) and acute myeloid leukemia (3 cases). All <jats:styled-content style=\"fixed-case\">IDCNs<\/jats:styled-content> associated with myeloid malignancies were limited to the skin, while most cases associated with lymphoma were limited to lymph nodes. Reported responses of cutaneous lesions to ultraviolet phototherapy are encouraging, while systemic chemotherapy is appropriate for clinically aggressive cases and treatment of associated malignancies. Recognition of the clinico\u2010morphologic spectrum of <jats:styled-content style=\"fixed-case\">IDCNs<\/jats:styled-content> should prevent misdiagnoses and prompt investigation of possible associated neoplasms.<\/jats:p>","DOI":"10.1111\/cup.13017","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T13:16:30Z","timestamp":1504790190000},"page":"958-963","source":"Crossref","is-referenced-by-count":29,"title":["Indeterminate dendritic cell neoplasm of the skin: A 2\u2010case report and review of the literature"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-6157","authenticated-orcid":false,"given":"Pedro","family":"Horna","sequence":"first","affiliation":[{"name":"Division of Hematopathology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Hematopathology and Laboratory Medicine H. Lee Moffitt Cancer Center  Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshan","family":"Idrees","sequence":"additional","affiliation":[{"name":"Department of Hematopathology and Laboratory Medicine H. 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