{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:28:53Z","timestamp":1789565333348,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Primary cutaneous acral <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ T\u2010cell lymphoma (acral <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>) is a new provisional entity characterized by acral skin lesions and an indolent course. We describe an extraordinary case characterized by relapsed nodules with <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ cytotoxic infiltrates on the left ear. After 35 years, the skin lesions spread to other acral sites, and a mass with the same histological features as the other skin lesions appeared on the nose. Multiple courses of chemotherapy led to stable disease. Histological examinations carried out at different times showed the gradual transformation of the neoplastic cells, with an increased proliferation index. Genomic analysis revealed losses in the regions harboring the genes involved in cell cycle control. This is the first case of an acral <jats:styled-content style=\"fixed-case\">CD8<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content> with a very long history of indolent nodular lesions progressing to extra\u2010cutaneous sites.<\/jats:p>","DOI":"10.1111\/cup.13020","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T11:02:45Z","timestamp":1502362965000},"page":"964-968","source":"Crossref","is-referenced-by-count":37,"title":["Primary cutaneous acral <scp>CD8<\/scp> positive T\u2010cell lymphoma with extra\u2010cutaneous involvement: A long\u2010standing case with an unexpected progression"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-1035","authenticated-orcid":false,"given":"Silvia","family":"Alberti\u2010Violetti","sequence":"first","affiliation":[{"name":"UOC Dermatologia, Fondazione IRCCS Ca\u2019 Granda \u2013 Ospedale Maggiore Policlinico  Milan 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