{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:12:41Z","timestamp":1785683561781,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"Background<\/jats:title>Subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL<\/jats:styled-content>) is a malignant primary cutaneous T\u2010cell lymphoma that shares significant clinical, histopathologic and immunophenotypic overlap with lupus erythematosus panniculitis (LEP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We performed immunohistochemistry for the MYC<\/jats:styled-content> oncoprotein on 23 cases of SPTCL<\/jats:styled-content> (1 CD8<\/jats:styled-content> negative) and 12 cases of LEP<\/jats:styled-content> to evaluate if there are quantitative or qualitative differences in protein expression of this marker in these entities.<\/jats:p><\/jats:sec>Results<\/jats:title>In SPTCL<\/jats:styled-content> cases, the percentage of all cells that were c\u2010Myc positive ranged from 0.8% to 16%, with a mean of 5.0% and a median of 4.4%. In contrast, in the LEP<\/jats:styled-content> cases, the percentage of c\u2010Myc\u2010positive cells in the cases ranged from 0.34% to 3.7%, averaged 1.4% and the median was 0.8%. The difference between the means of these 2 diagnostic categories was statistically significant. Fluorescence in situ hybridization performed on 4 cases of SPTCL<\/jats:styled-content> with a relatively high level of MYC<\/jats:styled-content> immunohistochemical staining, however, failed to demonstrate evidence of MYC<\/jats:styled-content><\/jats:italic> rearrangement or amplification.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our work demonstrates that MYC<\/jats:styled-content> expression levels differ between these 2 histologic mimics and suggests that this important oncoprotein may play a role in the pathogenesis of SPTCL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13025","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T14:42:35Z","timestamp":1502462555000},"page":"925-930","source":"Crossref","is-referenced-by-count":15,"title":["Immunohistochemistry reveals an increased proportion of MYC<\/scp>\u2010positive cells in subcutaneous panniculitis\u2010like T\u2010cell lymphoma compared with lupus panniculitis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0428-0199","authenticated-orcid":false,"given":"Sebastian","family":"Fernandez\u2010Pol","sequence":"first","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"De Stefano","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-5916","authenticated-orcid":false,"given":"Jinah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/133.2.303"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000596"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181a84f32"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.04.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-498329"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc904"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"key":"e_1_2_6_9_1","unstructured":"RasbandWS ImageJ U. 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