{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:33:24Z","timestamp":1783031604637,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Malignant mesothelioma (MM) is an aggressive and invasive neoplasm primarily affecting the pleura, peritoneum and pericardium. While mesothelioma commonly metastasizes to visceral organs, it has rarely been documented to involve the skin and subcutaneous tissue. There is a paucity of reports of cutaneous metastatic mesothelioma, and histologic examination is often challenging because the tumor closely mimics other primary and metastatic neoplasms. We report a case of a 75\u2010year\u2010old man presenting with a firm, hard nodule on his upper back, which on initial histologic evaluation resembled metastatic adenocarcinoma. However, upon review of his medical history and immunohistochemical evaluation of the lesion, the diagnosis of epithelioid MM metastatic to the skin was rendered. The purpose of this case report and review of the literature is to summarize the most effective available immunostains to aid in the diagnosis of this challenging entity, highlight the histologic similarities between metastatic epithelioid MM and other primary and metastatic neoplasms of the skin, and provide prognostic information for these rare tumors.<\/jats:p>","DOI":"10.1111\/cup.13026","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T14:52:35Z","timestamp":1502463155000},"page":"1057-1063","source":"Crossref","is-referenced-by-count":15,"title":["Epithelioid malignant mesothelioma metastatic to the skin: A case report and review of the literature"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1826-9844","authenticated-orcid":false,"given":"Rachel Elizabeth","family":"Ward","sequence":"first","affiliation":[{"name":"Department of Dermatology Wayne State University  Dearborn Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie Ann","family":"Ali","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Associates  Lombard Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Kuhar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Indiana University School of Medicine  Indianapolis Indiana"},{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.01094.x"},{"key":"e_1_2_4_3_1","first-page":"198729","article-title":"Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation","volume":"2013","author":"Falkenstern\u2010Ge RF","year":"2013","journal-title":"Case Rep Oncol Med"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21942"},{"issue":"4","key":"e_1_2_4_5_1","first-page":"482","article-title":"Subcutaneous metastases of sarcomatoid mesothelioma with its differential diagnosis on fine needle aspiration \u2013 a case report","volume":"48","author":"Patel T","year":"2005","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00219.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2003.00110.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1992.tb01602.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02813.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199706000-00011"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000100"},{"key":"e_1_2_4_12_1","first-page":"99","article-title":"M\u00e9tastases au niveau du cuir chevelu d'un m\u00e9soth\u00e9liome pleural","volume":"76","author":"Bazex A","year":"1968","journal-title":"Bull Soc Fr Dermatol Syphiligr"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3180ddc88f"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70297-8"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01669.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70275-8"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199106000-00014"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930140310"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-7-84"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmedc.2008.10.001"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e31802e465c"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2354.2003.00410.x"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(82)80037-X"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.02.046"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650340037016"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893422"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21300"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181e94121"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00151"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-3-21"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.346130089"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.8523"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2013.e41"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e31815e927e"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.180"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-21819-X_5"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-397-AOITTD"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2002.30236"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0214-OA"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12453"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000529"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.65"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14794-0"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.03.020"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051185"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:21:26Z","timestamp":1695561686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,11]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/cup.13026"],"URL":"https:\/\/doi.org\/10.1111\/cup.13026","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,11]]}}}