{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T02:54:18Z","timestamp":1782356058654,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005640","name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005640","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coagulation disorders contribute to the development of livedoid vasculopathy (LV). Elevated plasma levels of lipoprotein(a) [Lp(a)] are an independent risk factor for the development of cardiovascular disease and associated with hypercoagulable states. Increased serum Lp(a) levels have been reported in patients with LV and may have an important role in the pathogenesis of LV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate Lp(a) expression in skin lesions and circulating serum Lp(a) levels in patients with LV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin biopsy samples from 38 patients (27 women and 11 men) with active lesions diagnosed as LV and 9 samples of normal skin (5 women and 4 men) from control patients without LV were evaluated for skin expression of Lp(a) by immunohistochemistry. Plasma levels of Lp(a) were analyzed by immunoturbidimetry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that lesional skin in patients with LV expressed 10\u2010fold higher Lp(a) immunostaining than controls. High plasma levels of Lp(a) were observed in LV patients. We did not find a correlation (<jats:italic>P<\/jats:italic>\u2009=\u2009.02) between expression of Lp(a) in the skin and plasma levels of Lp(a) in patients with LV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased Lp(a) expression in lesional skin of LV patients suggests the role of Lp(a) in the thrombo\u2010occlusive vasculopathy observed in this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13043","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T11:23:49Z","timestamp":1505301829000},"page":"1033-1037","source":"Crossref","is-referenced-by-count":17,"title":["Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9020-109X","authenticated-orcid":false,"given":"Danielle P.G.S.","family":"Espinel","sequence":"first","affiliation":[{"name":"Dermatology Department of Hospital das Cl\u00ednicas University of Sao Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais B.","family":"Di Giacomo","sequence":"additional","affiliation":[{"name":"Dermatology Department of Hospital das Cl\u00ednicas University of Sao Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais P.","family":"Pincelli","sequence":"additional","affiliation":[{"name":"Dermatology Department of Hospital das Cl\u00ednicas University of Sao Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiura V.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Investigative Dermatology and Immunodeficiencies University of Sao Paulo Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam 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