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However, autoimmune toxicities are common and often significant adverse events with these agents. While rash and pruritus remain the most common cutaneous complications in treated patients, novel dermatologic toxicities related to immune checkpoint blockade continue to emerge as the number of patients exposed to immunotherapy increases. Here, we describe 2 patients treated with combination immunotherapy with ipilimumab and nivolumab who developed painful subcutaneous nodules. Although the findings were clinically concerning for disease recurrence, histopathologic examination of biopsies from the lesions revealed a subcutaneous mixed septal and lobular erythema nodosum\u2010like panniculitis. Notably, neither patient received immunosuppressive therapy for these lesions, which subsequently remained stable, and both patients\u2019 cancer remained controlled. These cases show that the dermatologic toxicity profile of immune checkpoint blockade is diverse and continues to expand, and illustrates that recognition of such toxicities is critical to optimal patient management.<\/jats:p>","DOI":"10.1111\/cup.13044","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T11:25:25Z","timestamp":1505301925000},"page":"1080-1086","source":"Crossref","is-referenced-by-count":53,"title":["Erythema nodosum\u2010like panniculitis mimicking disease recurrence: A novel toxicity from immune checkpoint blockade therapy\u2014Report of 2 patients"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-6222","authenticated-orcid":false,"given":"Michael T.","family":"Tetzlaff","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Texas MD Anderson Cancer Center  Houston Texas"},{"name":"Department of Translational and Molecular Pathology The University of Texas MD 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