{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:34:04Z","timestamp":1778924044882,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Talimogene laherparepvec (TVEC) is the first oncolytic viral immunotherapy approved by the FDA, for advanced melanoma consisting of genetically modified herpes simplex type 1 virus which selectively replicates causing tumor lysis, expressing granulocyte macrophage\u2010colony stimulating factor (GM\u2010CSF) and activating dendritic cells. Intratumoral injection of TVEC produces objective response in 41% of stage IIB\u2010IV M1a melanoma. However, clinical response assessment can be problematic due to immune\u2010related inflammation at established tumor sites. Herein, we report 5 cases of granulomatous dermatitis developing at sites of TVEC injection associated with pathologic complete response in 4 of 5 patients. Over 5\u2009months, TVEC injections were administrated in a median of 20 tumors per patient for 9 median doses prior to biopsy of persistent, indurated nodules. Granulomatous dermatitis with melanophages and melanin pigment incontinence was observed in all samples without evidence of melanoma cells in 4 patients. The fifth patient was rendered melanoma\u2010free by resection of the 1 nodule out of 4 with persistent tumor. Repetitive administration of TVEC or other oncolytic viral immunotherapies mimicking unresolved infection can produce granulomatous inflammation confounding assessment of the degree of tumor response and need for additional TVEC therapy. Tumor biopsies are encouraged after 4 to 6\u2009months of TVEC administration to differentiate melanoma from granulomatous inflammation. Patients with confirmed granulomatous dermatitis replace continued with remained in remission after treatment discontinuation. Inflammatory nodules typically regress spontaneously.<\/jats:p>","DOI":"10.1111\/cup.13048","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T14:06:45Z","timestamp":1506089205000},"page":"48-53","source":"Crossref","is-referenced-by-count":21,"title":["Chronic granulomatous dermatitis induced by talimogene laherparepvec therapy of melanoma metastases"],"prefix":"10.1111","volume":"45","author":[{"given":"Ashlyn S.","family":"Everett","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Pavlidakey","sequence":"additional","affiliation":[{"name":"Dermatopathology Services, Division of Dermatology and Pathology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo M.","family":"Contreras","sequence":"additional","affiliation":[{"name":"Department of Surgery \u2013 General Surgery Oncology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer F.","family":"De Los Santos","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Navigate BioPharma Services, Inc. A Novartis Subsidiary  Carlsbad California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana B.","family":"McKee","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard L.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Surgery and Medicine Rutgers University  New Brunswick New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Conry","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology University of Alabama at Birmingham  Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3377"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0238-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S115245"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63951-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2007.08.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.2.242"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12531"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000281"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13958"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:52:01Z","timestamp":1695516721000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/cup.13048"],"URL":"https:\/\/doi.org\/10.1111\/cup.13048","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,26]]}}}