{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:22:11Z","timestamp":1770488531377,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Primary large cell neuroendocrine carcinomas of the skin are exceptionally rare and can be diagnosed only when a metastasis from another organ has been excluded. We report the case of a 62\u2010year\u2010old woman with a cutaneous papule on the mid\u2010chest which generated a differential diagnosis of vascular lesion and basal cell carcinoma. Following excision, microscopic evaluation revealed a dermal large cell undifferentiated carcinoma, with a brisk mitotic rate and focal geographic necrosis. Mucin production was absent. On immunohistochemistry, the lesion expressed CK7, AE1AE3, CK8\/18, chromogranin, synaptophysin, CD56, calcitonin (patchy) and TTF\u20101 (minimal focal). Stains for neurofilament, CK20, CK5\/6, p40, p63, SOX10, MART\u20101, EMA, CEA, ER\/PR, GATA3, GCDFP, mammoglobin, PAX\u20108, CDX2, napsin, ERG and MCPyV proved negative. The histopathological diagnosis was of a large cell neuroendocrine carcinoma, probably metastatic. The patient underwent comprehensive clinical, laboratory and radiographic investigations and no underlying primary carcinoma was detected. During a 20\u2010month follow\u2010up period with an oncologist, the patient remains well and free of any apparent carcinoma. This suggests a primary large cell neuroendocrine carcinoma of skin. To date, 3 such cases have been reported in Japanese patients. This is the first in a Caucasian resident of North America.<\/jats:p>","DOI":"10.1111\/cup.13051","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T16:20:12Z","timestamp":1506615612000},"page":"54-58","source":"Crossref","is-referenced-by-count":10,"title":["Primary large cell neuroendocrine carcinoma of the skin: An under\u2010recognized entity and a mimic of metastatic disease"],"prefix":"10.1111","volume":"45","author":[{"given":"Ian Marie","family":"Lano","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nova Scotia Health Authority (Central Zone)  Halifax Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Rayson","sequence":"additional","affiliation":[{"name":"Department of Medicine Nova Scotia Health Authority (Central Zone)  Halifax Canada"},{"name":"Faculty of Medicine Dalhousie University  Halifax Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Arnason","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nova Scotia Health Authority (Central Zone)  Halifax Canada"},{"name":"Faculty of Medicine Dalhousie University  Halifax Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9246-4317","authenticated-orcid":false,"given":"Noreen M.G.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nova Scotia Health Authority (Central Zone)  Halifax Canada"},{"name":"Department of Medicine Nova Scotia Health Authority (Central Zone)  Halifax Canada"},{"name":"Faculty of Medicine Dalhousie University  Halifax Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-6053(00)80013-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00502.x"},{"issue":"4","key":"e_1_2_5_4_1","first-page":"802","article-title":"Primary cutaneous neuroendocrine tumor (atypical carcinoid) expressing KIT and PDGFRA with myoepithelial differentiation: a case report with immunohistochemical and molecular genetic studies","volume":"6","author":"Terada T","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199712000-00014"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000170348.40057.60"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318159b45e"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12794"},{"key":"e_1_2_5_9_1","first-page":"1665","article-title":"Cervical soft tissue metastasis of typical carcinoid tumor preceding diagnosis of primary by 4 years","volume":"87","author":"Naschitz JE","year":"1992","journal-title":"Am J Gastrenterol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896913516672"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.10.022"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02158.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.09.011"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.148"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00759.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:51:44Z","timestamp":1695516704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,7]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/cup.13051"],"URL":"https:\/\/doi.org\/10.1111\/cup.13051","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,7]]}}}