{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:32:13Z","timestamp":1788280333352,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Miraca Life Sciences Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p><jats:italic>ALK<\/jats:italic> rearrangements occur in up to 10% of spitzoid melanocytic neoplasms. No reported cases have shown homozygous deletion of 9p21 (<jats:italic>CDKN2A<\/jats:italic>) or gains of 6p25 (<jats:italic>RREB1<\/jats:italic>) or 11q13 (<jats:italic>CCND1<\/jats:italic>), which have been associated with aggressive clinical behavior. Here we report 2 unique cases. Case 1 occurred in a 9\u2010year\u2010old male with a 14\u2010mm nodule on the anterior left thigh. Biopsy revealed an ALK\u2010positive Spitz tumor containing an irregular nodule of densely packed melanocytes with increased mitoses and loss of p16 immunoreactivity. FISH analysis showed homozygous deletion of 9p21 and gain of 6p25. Sentinel lymph node biopsy revealed small subcapsular foci of tumor. Case 2 occurred in a 7\u2010year\u2010old female with a 12\u2010mm nodule on the anterior right ankle. Biopsy revealed an ALK\u2010positive Spitz tumor containing an expansile nodule of pleomorphic epithelioid melanocytes with numerous mitoses and loss of p16 immunoreactivity. By FISH, the nodule showed homozygous deletion of 9p21 and gains of 6p25 and 11q13. Our cases show the transformation of tumors produced by an activating kinase fusion gene (<jats:italic>ALK<\/jats:italic>) through secondary genetic changes including loss of tumor suppressor activity (<jats:italic>CDKN2A<\/jats:italic>). Long\u2010term follow up will be important to further define the behavior of these unique Spitz tumors.<\/jats:p>","DOI":"10.1111\/cup.13057","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T14:16:37Z","timestamp":1507904197000},"page":"136-140","source":"Crossref","is-referenced-by-count":14,"title":["Atypical ALK\u2010positive Spitz tumors with 9p21 homozygous deletion: Report of two cases and review of the literature"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5895-6716","authenticated-orcid":false,"given":"Andrew J.","family":"Rand","sequence":"first","affiliation":[{"name":"Miraca Life Sciences  Newton Massachusetts"},{"name":"Department of Dermatology Tufts Medical Center  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy L.","family":"Flejter","sequence":"additional","affiliation":[{"name":"Miraca Life Sciences  Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Dowling","sequence":"additional","affiliation":[{"name":"Miraca Life Sciences  Newton Massachusetts"},{"name":"Department of Dermatology Tufts Medical Center  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M.","family":"Brooke","sequence":"additional","affiliation":[{"name":"Miraca Life Sciences  Phoenix Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve M.","family":"Boland","sequence":"additional","affiliation":[{"name":"Department of Surgery Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Kroshinsky","sequence":"additional","affiliation":[{"name":"Department of Dermatology Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac R.","family":"Rosenblum","sequence":"additional","affiliation":[{"name":"Hudson Dermatology  Fishkill New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marier","family":"Hernandez\u2010Perez","sequence":"additional","affiliation":[{"name":"Miraca Life Sciences  Newton Massachusetts"},{"name":"Department of Dermatology Tufts Medical Center  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-3336","authenticated-orcid":false,"given":"Julie D. R.","family":"Reimann","sequence":"additional","affiliation":[{"name":"Miraca Life Sciences  Newton Massachusetts"},{"name":"Department of Dermatology Tufts Medical Center  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104658"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2015.12.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64609-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182498be5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.910"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4116"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4775"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.11.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8174"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000387"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000187"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000761"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896916630375"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182753de6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31828fc283"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11200"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:47:10Z","timestamp":1695570430000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/cup.13057"],"URL":"https:\/\/doi.org\/10.1111\/cup.13057","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]}}}