{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:51:01Z","timestamp":1770238261204,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T00:00:00Z","timestamp":1512432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/22927\u20107"],"award-info":[{"award-number":["2016\/22927\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>More than 200\u2009000 new cases of leprosy are detected worldwide annually. Physicians commonly have difficulty in differentiating tuberculoid form of leprosy (TL) from sarcoidosis\u2019 cutaneous manifestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin biopsies of 33 patients with TL and 24 with sarcoidosis were reviewed on hematoxylin and eosin\u2010 and Gomori\u2010stained sections, in order to find reliable criteria for distinguishing one disease from another.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine of the 24 features analyzed presented significant predictive value for diagnosis (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Predominance of tuberculoid granulomas in adnexal and neural distribution, and granulomas replacing the nerves localized within sweat gland glomeruli were predictive to TL diagnosis. For sarcoidosis, dermal fibrosis, back\u2010to\u2010back distribution of the granulomas, presence of atypical giant cells and plasma cells, greater number of conventional giant cells, and spared nerves beside the granuloma were predictive criteria. The median surface density of reticulin fibers was significantly higher in sarcoidosis (3.44) than in TL (2.99). Nonetheless, using logistic regression, this variable did not discriminate between the diseases (<jats:italic>P<\/jats:italic>\u2009=\u2009.096).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Isolated histological features are not fully predictive to differentiate the 2 diseases. However, those with statistical value can assist this distinction in diagnostic practice. Although the results of the analysis of the reticulin fibers density did not tell apart TL from sarcoidosis, they corroborate the idea of fiber fragmentation within tuberculoid leprosy granulomas, reiterating the importance of morphometry in the histological examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13064","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T09:56:38Z","timestamp":1508925398000},"page":"111-117","source":"Crossref","is-referenced-by-count":6,"title":["Histomorphometric approach to differentiate skin lesions of tuberculoid leprosy from sarcoidosis"],"prefix":"10.1111","volume":"45","author":[{"given":"Fabiane Leonel","family":"Utino","sequence":"first","affiliation":[{"name":"Pathology Department University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gislaine Vieira","family":"Damiani","sequence":"additional","affiliation":[{"name":"Pathology Department University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Garcia","sequence":"additional","affiliation":[{"name":"Pathology Department University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e2nia Cristina Benetti","family":"Soares","sequence":"additional","affiliation":[{"name":"Pathology Department University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Fantelli","family":"Stelini","sequence":"additional","affiliation":[{"name":"Pathology Department University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Eduardo Neves Ferreira","family":"Velho","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elemir Macedo","family":"de Souza","sequence":"additional","affiliation":[{"name":"Dermatology Department University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Let\u00edcia","family":"Cintra","sequence":"additional","affiliation":[{"name":"Pathology Department University of Campinas (UNICAMP)  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"issue":"36","key":"e_1_2_6_2_1","first-page":"461","article-title":"Global leprosy update 2014: need for early case detection","volume":"90","author":"Ministry of Health, WHO","year":"2015","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_6_3_1","unstructured":"Ministry of Health Brasil [Internet document]. Registro ativo: n\u00famero e percentual Casos novos de hansen\u00edase: n\u00famero coeficiente e percentual faixa et\u00e1ria classifica\u00e7\u00e3o operacional sexo grau de incapacidade contatos examinados por estados e regi\u00f5es.http:\/\/portalsaude.saude.gov.br\/images\/pdf\/2015\/julho\/27\/Dados-2014?-final.pdf. Accessed April 7 2016."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200209000-00014"},{"key":"e_1_2_6_5_1","first-page":"19","article-title":"Sarcoidosis: the Indian scene","volume":"3","author":"Gupta SK","year":"1993","journal-title":"Indian J Clin Pract"},{"key":"e_1_2_6_6_1","first-page":"307","article-title":"Hansen's disease in a patient with a history of sarcoidosis","volume":"68","author":"Burdick AE","year":"2000","journal-title":"Int J Lepr Other Mycobact Dis"},{"issue":"3","key":"e_1_2_6_7_1","first-page":"455","article-title":"Cutaneous sarcoidosis masquerading as relapsed borderline tuberculoid leprosy?","volume":"61","author":"Kaur S","year":"1993","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"e_1_2_6_8_1","first-page":"657","article-title":"Sarcoidosis masquerading as leprosy, pulmonary tuberculosis and urolithiasis","volume":"38","author":"Singh K","year":"1990","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_6_9_1","first-page":"318","article-title":"Tuberculoid leprosy or sarcoidosis? A diagnostic dilemma","volume":"54","author":"Ramanujam K","year":"1982","journal-title":"Lepr India"},{"key":"e_1_2_6_10_1","first-page":"65","article-title":"Tuberculoid leprosy and tuberculosis skin\u2014a comparative histopathological study","volume":"49","author":"Nirmala V","year":"1977","journal-title":"Lepr India"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0758-5"},{"issue":"1","key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/infdis\/162.1.193","article-title":"The use of a specific DNA probe and polymerase chain reaction for the detection of Mycobacterium leprae","volume":"162","author":"Williams DL","year":"1990","journal-title":"J Infect Dis"},{"key":"e_1_2_6_13_1","first-page":"12","article-title":"DNA amplification for detection of leprosy and assessment of efficacy of leprosy chemotherapy","volume":"66","author":"Kampirapap K","year":"1998","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"e_1_2_6_14_1","first-page":"519","article-title":"Enigmas in sarcoidosis","volume":"162","author":"Chesnutt AN","year":"1995","journal-title":"West J Med"},{"issue":"9","key":"e_1_2_6_15_1","first-page":"2041","article-title":"Sarcoidosis: a primary care review","volume":"58","author":"Mark H","year":"1998","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1986.tb04282.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-2720.2004.01392.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1055\/s-2002-36525","article-title":"Cutaneous sarcoidosis","volume":"23","author":"Epstein WL","year":"2002","journal-title":"Semin Respir Crit Care Med"},{"key":"e_1_2_6_19_1","first-page":"1581","article-title":"Cutaneous sarcoidosis: a dermatologic masquerader","volume":"65","author":"Katta R","year":"2002","journal-title":"Am Fam Physician"},{"issue":"8","key":"e_1_2_6_20_1","first-page":"1725","article-title":"Isolated cutaneous sarcoidosis: a new insight into the old entity","volume":"7","author":"Sharath HK","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70070-X"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114596"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868100-00003"},{"issue":"4","key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4103\/0378-6323.159929","article-title":"A randomized controlled trial to compare cure and relapse rate of paucibacillary multidrug therapy with monthly rifampicin, ofloxacin, and minocycline among paucibacillary leprosy patients in Agra district, India","volume":"81","author":"Kumar A","year":"2015","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_6_25_1","unstructured":"2004 Blackwell Publishing Inc Malden Massachusetts USA DJ Gawkrodger T Burns S Breathnach N Cox C Griffiths Sarcoidosis. Rook's Textbook of Dermatology"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1999.tb01844.x"},{"issue":"1","key":"e_1_2_6_27_1","first-page":"54","article-title":"Clinico\u2010pathological study of cutaneous granulomatous lesions\u2014a 5 yr experience in a tertiary care hospital in India","volume":"11","author":"Chakrabarti S","year":"2016","journal-title":"Iran J Pathol"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12248"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01337.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.10.003"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.5.395"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/19.8.725"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb01493.x"},{"key":"e_1_2_6_34_1","first-page":"181","volume-title":"Leprosy: The Granulomatous Disorders","author":"Zumla A","year":"1999"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12484"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00157.x"},{"issue":"4","key":"e_1_2_6_37_1","first-page":"449","article-title":"Isolation of a non\u2010collagenous reticulin component and its primary characterization","volume":"54","author":"Pras M","year":"1973","journal-title":"Br J Exp Pathol"},{"issue":"2","key":"e_1_2_6_38_1","first-page":"213","article-title":"Reticulin in the different varieties of tuberculoid leprosy: its differential diagnostic value","volume":"20","author":"Gomez OJ","year":"1952","journal-title":"Int J Lepr"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:46:20Z","timestamp":1695570380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,5]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/cup.13064"],"URL":"https:\/\/doi.org\/10.1111\/cup.13064","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,5]]}}}