{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:21:39Z","timestamp":1766269299506,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,10]],"date-time":"2017-12-10T00:00:00Z","timestamp":1512864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>We present an unusual case of human T\u2010cell leukemia\u2010lymphoma virus type 1 (HTLV\u20101)\u2010associated adult T\u2010cell leukemia\/lymphoma in an human immunodeficiency virus (HIV) patient who presented with non\u2010diffuse, papular, waxing and waning cutaneous eruptions. The patient is a 61\u2010year\u2010old Haitian male with history of HIV on highly active antiretroviral therapy (HAART) who presented with multiple painful pink papules on his distal fingers and back for more than a year with a waxing and waning course. Skin biopsy demonstrated a CD4+, CD25+, CD8\u2212 lymphocytic proliferation with a clonal T\u2010cell receptor gene rearrangement. Peripheral blood demonstrated lymphocytosis with a CD4:CD8 ratio greater than 20:1 and an identical T\u2010cell receptor (TCR) clone as that in the biopsy. HTLV\u20101 antibodies and PCR testing for HTLV virus were positive. Retrospective review of CBCs during the past 8 years demonstrated chronic lymphocytosis with a sharp increase in absolute CD4 counts corresponding to the onset of rash. The patient lacked systemic symptoms after 6 months follow\u2010up.<\/jats:p>","DOI":"10.1111\/cup.13078","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T11:10:22Z","timestamp":1509621022000},"page":"171-175","source":"Crossref","is-referenced-by-count":7,"title":["Indolent, waxing and waning cutaneous presentation of HTLV\u20101\u2010associated adult T\u2010cell leukemia\/lymphoma in an HIV\u20101\u2010positive patient"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-1141","authenticated-orcid":false,"given":"Justin D.","family":"Richey","sequence":"first","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical School  Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical School  Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"April C.","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Massachusetts Medical School  Worcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90132-H"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6981847"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.10.006"},{"issue":"1","key":"e_1_2_4_7_1","first-page":"8","article-title":"HIV\/human T\u2010cell lymphotropic virus coinfection revisited: impact on AIDS progression","volume":"11","author":"Brites C","year":"2009","journal-title":"AIDS Rev"},{"issue":"15","key":"e_1_2_4_8_1","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1097\/00002030-200110190-00023","article-title":"Co\u2010infection with HTLV\u20101 is associated with a shorter survival time for HIV\u20101\u2010infected patients in Bahia, Brazil","volume":"15","author":"Brites C","year":"2001","journal-title":"AIDS (London, England)"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0342"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003303421304"},{"issue":"10","key":"e_1_2_4_11_1","first-page":"704","article-title":"Adult T\u2010cell leukemia associated with HTLV\u20101 in a HIV\u20102 seropositive African","volume":"121","author":"Mahe A","year":"1994","journal-title":"Ann Dermatol Venereol"},{"issue":"4","key":"e_1_2_4_12_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJM200007273430416","article-title":"HIV\u20101 and an HTLV\u2010II\u2010associated cutaneous T\u2010cell lymphoma","volume":"343","author":"Guitart J","year":"2000","journal-title":"N Engl J Med"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002275"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000027"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.10.1689"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0684"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/333776a0"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6872-5_15"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.11.060"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:47:01Z","timestamp":1695570421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,10]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/cup.13078"],"URL":"https:\/\/doi.org\/10.1111\/cup.13078","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"type":"print","value":"0303-6987"},{"type":"electronic","value":"1600-0560"}],"subject":[],"published":{"date-parts":[[2017,12,10]]}}}