{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:48:44Z","timestamp":1777477724233,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Wide local excisions (WLEs) are frequently undertaken in the management of cutaneous melanoma; however, there is a considerable variability in their macroscopic sampling. The aim of our study was to establish evidence\u2010based guidelines for the macroscopic handling of these specimens with a subsequent review of the impact on our service.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group of 128 cases with initial biopsy and subsequent WLE in our institution in 2010 were identified by a computer\u2010generated search. From analysis of this group, guidelines for macroscopic sampling were derived with a repeat search performed in 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Residual melanoma was detected only in those cases in which the original specimen had clear margins of \u22641 mm or with a pigmented lesion. A 32% increase in case numbers was noted over this period with a reduction of 6.2% in block numbers. Average block numbers per case were reduced by 2.3 (30.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have shown that for WLE specimens with no evidence of a macroscopic lesion and clear margins on original biopsy, little is to be gained from extensive sampling. In these cases we recommend a maximum of 3 blocks per case. Reduction in sampling based on this evidence would result in saving valuable laboratory resources.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13083","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T11:22:58Z","timestamp":1511436178000},"page":"198-203","source":"Crossref","is-referenced-by-count":4,"title":["Sampling of wide local excision specimens in cutaneous malignant melanoma"],"prefix":"10.1111","volume":"45","author":[{"given":"Cassie","family":"Fives","sequence":"first","affiliation":[{"name":"Department of Pathology Cork University Hospital  Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2234-3739","authenticated-orcid":false,"given":"Cynthia C. B. 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