{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:03:05Z","timestamp":1783620185706,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Hyperpigmentation in pregnancy is a common phenomenon, experienced to some degree by up to 90% of pregnant women. It mainly involves sun\u2010exposed areas, but it can extend to non\u2010exposed zones. Cases with extensive hyperpigmentation are rarely reported. In this paper, we describe the case of a 30\u2010year\u2010old phototype V woman in her 37th week of pregnancy, who presented with brownish hyperpigmentation of the skin in extensive areas, including both axillae, the abdomen and the lowest part of the back. In the abdomen, there was a reinforcement of the hyperpigmentation through the linea nigra and the umbilicus. The hyperpigmentation affected the buttocks as well and involved the intertriginous area between them. Histopathologic analysis showed a hyperpigmented basal layer of the epidermis with no melanocytic atypia or melanocytic nests. Histochemical staining for iron did not show any deposits. Immunohistochemical studies for HMB\u201045, Melan A and SOX10 demonstrated an increased number of melanocytes. There was hyperpigmentation of basal layer keratinocytes. We also performed immunohistochemical stains for estrogen and progesterone receptors, which were both negative. The patient was examined 3 months after delivery, evidencing a significant clearing of the lesions.<\/jats:p>","DOI":"10.1111\/cup.13108","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T12:38:45Z","timestamp":1516279125000},"page":"286-289","source":"Crossref","is-referenced-by-count":3,"title":["Histopathological findings in pregnancy associated cutaneous hyperpigmentation"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-2364","authenticated-orcid":false,"given":"Angel","family":"Fernandez\u2010Flores","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Hospital El Bierzo  Ponferrada Spain"},{"name":"Department CellCOM\u2010SB Group Biomedical Investigation Institute of A Coru\u00f1a  A Coru\u00f1a Spain"},{"name":"Department of Cellular Pathology Hospital de la Reina  Ponferrada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M.","family":"Barja","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital El Bierzo  Ponferrada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Vilas\u2010Sueiro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital El Bierzo  Ponferrada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Alija","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital El Bierzo  Ponferrada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70083-0"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540200600308"},{"issue":"2","key":"e_1_2_4_4_1","first-page":"233","article-title":"Skin changes and diseases associated with pregnancy","volume":"52","author":"Wade TR","year":"1978","journal-title":"Obstet Gynecol"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(96)00108-3"},{"issue":"5","key":"e_1_2_4_6_1","first-page":"685","article-title":"The incidence of lower mid\u2010trunk hyperpigmentation (linea nigra) is affected by sex hormone levels","volume":"97","author":"George AO","year":"2005","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-464"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-0963.2001.04556.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4869.1016"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050446"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12404"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03638.x"},{"issue":"5","key":"e_1_2_4_13_1","first-page":"463","article-title":"Estrogen receptor expression in melasma: results from facial skin of affected patients","volume":"7","author":"Lieberman R","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12186"},{"issue":"7","key":"e_1_2_4_15_1","first-page":"455","article-title":"A retrospective study on the clinical presentation and treatment outcome of melasma in a tertiary dermatological referral centre in Singapore","volume":"40","author":"Goh CL","year":"1999","journal-title":"Singapore Med J"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.84722"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02470.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04430.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:19:47Z","timestamp":1695507587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/cup.13108"],"URL":"https:\/\/doi.org\/10.1111\/cup.13108","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,9]]}}}