{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:37:40Z","timestamp":1780623460323,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Histologic differentiation of melanoma in situ (MIS) from solar keratosis on chronically sun\u2010damaged skin is challenging. The first\u2010line immunostain is usually MART\u20101\/Melan\u2010A, which can exaggerate the epidermal melanocytes, causing a diagnostic pitfall for MIS. By comparing MART\u20101 and SOX10 immunostaining, we scored the percentage of epidermal melanocytes per 2\u2010mm diameter fields in pigmented actinic keratosis (<jats:italic>n<\/jats:italic>\u2009=\u200916), lichenoid keratosis (<jats:italic>n<\/jats:italic>\u2009=\u20097), junctional melanocytic nevus (<jats:italic>n<\/jats:italic>\u2009=\u20096), keratosis with atypical melanocytic proliferation (<jats:italic>n<\/jats:italic>\u2009=\u200917) and MIS (<jats:italic>n<\/jats:italic>\u2009=\u200910). These cases represented an older population (68 years median age) and the head and neck (50%) was the most common anatomic site. MART\u20101 score was significantly higher than SOX10 (<jats:italic>P<\/jats:italic> value &lt;.05) in solar keratoses, but showed no difference in detecting melanocytic proliferations, demonstrating their equal detection rate of melanocytes. The sensitivity of both MART\u20101 and SOX10 was 100%, while their specificities were 17% and 96%, respectively. These results show that SOX10 is more specific than MART\u20101 in distinguishing epidermal melanocytes on sun\u2010damaged skin by avoiding overdiagnosis of melanoma.<\/jats:p>","DOI":"10.1111\/cup.13115","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T18:41:06Z","timestamp":1517251266000},"page":"263-268","source":"Crossref","is-referenced-by-count":21,"title":["A quantitative comparison between SOX10 and MART\u20101 immunostaining to detect melanocytic hyperplasia in chronically sun\u2010damaged skin"],"prefix":"10.1111","volume":"45","author":[{"given":"Sonal","family":"Muzumdar","sequence":"first","affiliation":[{"name":"School of Medicine University of Connecticut  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Argraves","sequence":"additional","affiliation":[{"name":"School of Medicine University of Connecticut  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arni","family":"Kristjansson","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Connecticut Health Center  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Ferenczi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Connecticut Health Center  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-7609","authenticated-orcid":false,"given":"Soheil S.","family":"Dadras","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Connecticut Health Center  Farmington Connecticut"},{"name":"Department of Pathology University of Connecticut Health Center  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(03)00234-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200410000-00003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318291485c"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01763.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01946.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01688.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00891.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw115"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200106000-00004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181658c14"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01568.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:19:20Z","timestamp":1695507560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/cup.13115"],"URL":"https:\/\/doi.org\/10.1111\/cup.13115","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]}}}