{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:16:50Z","timestamp":1785291410085,"version":"3.55.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Melanoma may undergo dedifferentiation and sarcomatous transformation with loss of melanocytic markers. Dedifferentiated melanoma rarely forms true rhabdomyoblasts with skeletal muscle immunophenotype (rhabdomyosarcomatous heterologous component). A 52\u2010year\u2010old woman was diagnosed with invasive melanoma (Breslow thickness 0.83\u2009mm) of the upper back in 2012, treated by wide local excision only. In 2013, an axillary mass was excised to show metastatic melanoma with 2 morphologies: an epithelioid morphology expressing S100 and MART\u20101 and a spindled morphology with loss of melanocytic markers but strong expression of desmin. This metastasis was found to have <jats:italic>BRAF V600E<\/jats:italic> mutation. In 2015, a thoracic epidural mass biopsy showed atypical spindle cells with focal HMB\u201045 but essentially no S100 expression. Numerous rhabdomyoblasts, some with striations that were strongly positive for desmin and myogenin, were present. In 2016, a right nephrectomy was performed for metastasis to the kidney, and showed sheets of spindle cells and rhabdomyoblasts expressing desmin and myogenin but not S100. Only focal areas demonstrated expression of HMB\u201045 and SOX\u201010, supporting the melanocytic origin of the tumor. The numerous rhabdomyoblasts and the loss of S100 expression in the metastatic lesions in this case could have easily led to misdiagnosis if the clinical history was not known.<\/jats:p>","DOI":"10.1111\/cup.13122","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T04:12:46Z","timestamp":1517890366000},"page":"360-364","source":"Crossref","is-referenced-by-count":28,"title":["Metastatic melanoma with dedifferentiation and extensive rhabdomyosarcomatous heterologous component"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7855-9424","authenticated-orcid":false,"given":"Katelynn","family":"Campbell","sequence":"first","affiliation":[{"name":"Department of Pathology University of Arkansas for Medical Sciences  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asangi R.","family":"Kumarapeli","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arkansas for Medical Sciences  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neriman","family":"Gokden","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arkansas for Medical Sciences  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni M.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arkansas for Medical Sciences  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hutchins","sequence":"additional","affiliation":[{"name":"Department of Oncology University of Arkansas for Medical Sciences  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7397-2159","authenticated-orcid":false,"given":"Jerad M.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Arkansas for Medical Sciences  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0553-5"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02823.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896917700725"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896914531817"},{"issue":"2","key":"e_1_2_3_6_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/PAS.0000000000000527","article-title":"Metastatic malignant melanoma with complete loss of differentiation markers (undifferentiated+\/dedifferentiated melanoma): analysis of 14 patients emphasizing phenotypic plasticity and the value of molecular testing as surrogate diagnostic marker","volume":"40","author":"Agaimy A","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896906295775"},{"key":"e_1_2_3_8_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1056\/NEJMc0707079","article-title":"Malignant melanoma with metastatic rhabdomyosarcomatoid transdifferentiation","volume":"58","author":"Gattenl\u00f6hner S","year":"2008","journal-title":"N Engl J Med"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896913510031"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000478"},{"issue":"11","key":"e_1_2_3_11_1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/cup.12007","article-title":"Primary cutaneous rhabdomyosarcoma: a clinicopathologic review of 11 cases","volume":"39","author":"Marbuger TB","year":"2012","journal-title":"J Cutan Pathol"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:58:04Z","timestamp":1695571084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/cup.13122"],"URL":"https:\/\/doi.org\/10.1111\/cup.13122","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}