{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:41:11Z","timestamp":1760985671498},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To further characterize the micromorphometric immunological pattern to metastatic melanoma in sentinel lymph node (SLN) biopsies and completion lymph node (CLN) dissections and their relation to 5\u2010year overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort of 49 patients from 1996 to 2005 with a positive SLN who underwent CLN dissection (CLD) was studied. Micromorphometric characteristics included follicular center count (FCC)\/profile, sinus histiocytosis, metastatic size, tumor infiltrating lymphocytes (intranodal), paracortical dendritic cells, germinal center reaction and morphology. Comparison of Kaplan\u2010Meier survival curves used the exact log\u2010rank statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the high\u2010FCC (<jats:italic>n<\/jats:italic>\u2009=\u20095\u201051) vs the low\u2010FCC (<jats:italic>n<\/jats:italic>\u2009&lt;\u20095) lymph nodes, a delayed separation occurred at 3\u2009years, with 5\u2010year OS rates being 73% vs 54% in the high\u2010 and low\u2010FCC groups, respectively. Improved survival up to 3\u2009years was also noted in CLDs that showed a higher FCC when compared to the prior SLN. Patients with metastatic deposits &gt;2 mm had significantly lower 5\u2010year survival (both &lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nodal micromorphometric features (ie, FCC) are probably related to host immune response to metastasis. Quantitative evaluation of lymphoid follicular centers could provide valuable prognostic information to help to stratify patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13127","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T13:32:52Z","timestamp":1518701572000},"page":"377-386","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Histological immune response patterns in sentinel lymph nodes involved by metastatic melanoma and prognostic significance"],"prefix":"10.1111","volume":"45","author":[{"given":"James","family":"Abbott","sequence":"first","affiliation":[{"name":"Department of Medicine, Pennsylvania Hospital  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Biostatistic and Epidemiology University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgos","family":"Karakousis","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Czerniecki","sequence":"additional","affiliation":[{"name":"Department of Breast Oncology Moffitt Cancer Center  Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis A.","family":"Gimotty","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania  Philadelphia 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