{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:19:47Z","timestamp":1782602387164,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Mycosis fungoides in palmoplantar localization (MFPP) is a rare variant of MF that is confined to the hands and feet. Patients commonly receive treatment over many years for suspected palmoplantar dermatitis before the diagnosis is made. Most MFPP patients remain at patch or plaque stage, and often respond to treatment with radiotherapy. Herein, we describe a 77\u2010year\u2010old man who suffered 6\u2009years of hand and foot dermatitis that failed multiple treatments, most notably TNF\u2010\u03b1 inhibitors and mycophenolate mofetil. He eventually developed a tumor on the hand, which was biopsied to reveal a dense dermal infiltrate of large lymphocytes (CD3+\/CD4\u2010\/CD8\u2010\/TCR\u2010BetaF1+\/partial CD30+). A subsequent biopsy of an eczematous patch from his hand revealed an epidermotropic and syringotropic infiltrate comprised of smaller lymphocytes with a concordant immunophenotype and matching clonal peak with TCR gene rearrangement. He was diagnosed with MFPP and started on radiotherapy with a modest response; therefore, a decision was made to start brentuximab vedotin, which resulted in a complete response. MFPP is an exceedingly rare variant of MF that can show large\u2010cell transformation and progress in stage. We highlight a possible association between disease progression and immunosuppressants and the potential role for treatment with brentuximab.<\/jats:p>","DOI":"10.1111\/cup.13140","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T11:52:39Z","timestamp":1520423559000},"page":"458-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tumor\u2010stage mycosis fungoides in palmoplantar localization with large\u2010cell transformation and partial CD30 expression shows complete response to brentuximab vedotin"],"prefix":"10.1111","volume":"45","author":[{"given":"Anh Khoa","family":"Pham","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Surgery Dartmouth\u2010Hitchcock Medical Center, Geisel School of Medicine  Lebanon, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joi B.","family":"Carter","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Surgery Dartmouth\u2010Hitchcock Medical Center, Geisel School of Medicine  Lebanon, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora R.","family":"Ratcliffe","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth\u2010Hitchcock Medical Center Geisel School of Medicine  Lebanon, New Hampshire"},{"name":"Department of Pathology and Laboratory Medicine White River Junction VA Medical Center  White River Junction Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Fuld","sequence":"additional","affiliation":[{"name":"Section of Hematology and Oncology, Department of Medicine Dartmouth\u2010Hitchcock Medical Center, Geisel School of Medicine  Lebanon, New Hampshire"},{"name":"Department of Hematology and Oncology White River Junction VA Medical Center  White River Junction Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Lansigan","sequence":"additional","affiliation":[{"name":"Section of Hematology and Oncology, Department of Medicine Dartmouth\u2010Hitchcock Medical Center, Geisel School of Medicine  Lebanon, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Burnside","sequence":"additional","affiliation":[{"name":"Department of Dermatology White River Junction VA Medical Center  White River Junction Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Marshall A.","family":"Guill","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Surgery Dartmouth\u2010Hitchcock Medical Center, Geisel School of Medicine  Lebanon, New Hampshire"},{"name":"Department of Dermatology White River Junction VA Medical Center  White River Junction Vermont"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Zug","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Surgery Dartmouth\u2010Hitchcock Medical Center, Geisel School of Medicine  Lebanon, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Dartmouth\u2010Hitchcock Medical Center Geisel School of Medicine  Lebanon, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-0381","authenticated-orcid":false,"given":"Robert E.","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth\u2010Hitchcock Medical Center Geisel School of Medicine  Lebanon, New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"issue":"9","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1001\/archderm.1995.01690210082013","article-title":"Mycosis fungoides palmaris et plantaris","volume":"131","author":"Resnik KS","year":"1995","journal-title":"Arch 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lymphoma.https:\/\/www.fda.gov\/Drugs\/InformationOnDrugs\/ApprovedDrugs\/ucm584543.htm. 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