{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:40:27Z","timestamp":1782402027150,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T00:00:00Z","timestamp":1532390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>Checkpoint inhibitors (CPIs) restore the function of effector immunocytes to target and destroy cancer cells. Immune\u2010related adverse events (irAEs) are a consequence of immune reactivation, with unpredictable inflammatory response, loss of self\u2010tolerance, and development of autoimmunity. Adverse events from CPIs that present as dermatologic toxicities have diverse clinical and histopathologic features. CPI\u2010associated dermatologic toxicities may exhibit histopathologic features of lichenoid dermatitis, bullous pemphigoid, and granulomatous\/sarcoid\u2010like reactions. Suprabasal acantholytic dermatologic toxicities associated with CPIs are particularly rare but represent an emerging histopathologic pattern and include lichenoid dermatitis with suprabasal acantholysis\/vesicle formation to Grover disease (transient acantholytic dermatosis). Here, we report two patients who developed suprabasal acantholytic dermatologic toxicities during CPI therapy. One patient exhibited a CPI\u2010associated autoimmune blistering disease with paraneoplastic pemphigus (PNP)\u2010like features restricted to histopathology and immunofluorescence, while the other patient had Grover\u2010like lesions. A review of the literature revealed a spectrum of suprabasal acantholytic dermatologic toxicities associated CPIs that may present as lichenoid dermatitis with acantholysis\/vesicle formation, Grover\u2010like eruptions, and lesions with PNP\u2010like features restricted to histopathology and immunofluorescence. It is important for clinicians and pathologists to recognize the types of dermatologic toxicities associated with CPIs to direct appropriate therapeutic strategies.<\/jats:p>","DOI":"10.1111\/cup.13312","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T02:30:12Z","timestamp":1529980212000},"page":"764-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Suprabasal acantholytic dermatologic toxicities associated checkpoint inhibitor therapy: A spectrum of immune reactions from paraneoplastic pemphigus\u2010like to Grover\u2010like lesions"],"prefix":"10.1111","volume":"45","author":[{"given":"Wei\u2010Shen","family":"Chen","sequence":"first","affiliation":[{"name":"Section of Dermatopathology, Department of Pathology University of Texas MD Anderson Cancer Center  Houston 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