{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:21:47Z","timestamp":1761844907531,"version":"3.37.3"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/110\/409\/2011"],"award-info":[{"award-number":["E\u201026\/110\/409\/2011"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lipomatous neurofibroma (Lnf) is a histopathological variant with adipocytes noted among cells of cutaneous neurofibromas. We aimed to investigate the prevalence and clinicopathological features of Lnfs of neurofibromatosis 1 (NF1)\u2010associated cutaneous neurofibromas and to review the literature systematically. We also evaluated the expression of leptin (a hormone involved in lipid metabolism) in neurofibromas to better understand the pathogenesis of Lnfs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective histologic study was conducted on 229 cutaneous neurofibromas from 85 NF1 individuals. Leptin expression was immunohistochemically evaluated in 111 cutaneous neurofibromas. To systematically review the literature, two authors independently performed literature searches without year restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty (17.5%) neurofibromas were lipomatous. Lnfs were significantly larger lesions and associated with females. Eighteen (7.9%) of all neurofibromas had multinucleated floret\u2010like giant cells, and these were associated with Lnfs. All neurofibromas expressed leptin. We systematically reviewed 13 articles. Three large studies investigated Lnfs mainly in sporadic neurofibromas and suggested that 0.3% to 8.0% of tumors (NF1 and sporadic) are Lnfs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In NF1, Lnfs are common, mainly in larger tumors and women. All cutaneous NF1\u2010neurofibromas express leptin. It is unknown if the expression of leptin accounts for the lipomatous variant, but it may have a role in the pathogenesis of cutaneous neurofibroma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13315","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T07:44:27Z","timestamp":1530344667000},"page":"743-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and clinicopathological characteristics of lipomatous neurofibromas in neurofibromatosis 1: An investigation of 229 cutaneous neurofibromas and a systematic review of the literature"],"prefix":"10.1111","volume":"45","author":[{"given":"Rafaela Elvira","family":"Rozza\u2010de\u2010Menezes","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Brazil"},{"name":"Neurofibromatosis National Center (Centro Nacional de Neurofibromatose, CNNF)  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina de Almeida Ito","family":"Brum","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolle Cavalcante","family":"Gaglionone","sequence":"additional","affiliation":[{"name":"Graduate Program in Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Machado","family":"de Sousa Almeida","sequence":"additional","affiliation":[{"name":"Neurofibromatosis National Center (Centro Nacional de Neurofibromatose, CNNF)  Rio de Janeiro Brazil"},{"name":"Graduate Program in Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel 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