{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:32:49Z","timestamp":1787502769460,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melanoma remains a challenge to diagnose, especially when appearing on the background of chronically sun\u2010damaged skin (CSDS). Our goal was to identify and quantify the reflectance confocal microscopy (RCM) features of melanoma on non\u2010facial CSDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Included lesions were biopsy\u2010proven melanomas, from anatomic sites other than the face, neck, scalp and acral skin, with histopathologic finding of solar elastosis in the underlying dermis. All included lesions underwent clinical, dermoscopic and RCM imaging, obtained in a standardized fashion, prior to biopsy. All images were retrospectively analyzed by four observers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 33 melanomas from 33 patients with 63.6% male patients and overall mean age of 72.8\u2009years. The salient RCM features included an atypical honeycomb or disarranged epidermal pattern (81.8%), pagetoid infiltration of the epidermis by both round and\/or dendritic melanocytes (100%), focal proliferation of predominantly dendritic melanocytes as sheets (78.8%), foci with non\u2010edged papillae (84.8%), junctional thickening (60.6%), areas of irregular ring or meshwork pattern (78.8%), and underlying thickened collagen bundles (51.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non\u2010facial CSDS melanomas share features similar to other melanoma types including pagetoid cells and non\u2010edged papillae. The focal proliferation of dendritic pagetoid cells in sheets is similar to that seen in facial CSDS melanomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.13318","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T04:37:06Z","timestamp":1530679026000},"page":"754-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reflectance confocal microscopy features of melanomas on the body and non\u2010glabrous chronically sun\u2010damaged skin"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5813-0113","authenticated-orcid":false,"given":"Neda","family":"Shahriari","sequence":"first","affiliation":[{"name":"Department of Internal Medicine St. Mary's Hospital  Waterbury Connecticut"},{"name":"Department of Dermatology UCONN Health Center  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1844-8415","authenticated-orcid":false,"given":"Jane M.","family":"Grant\u2010Kels","sequence":"additional","affiliation":[{"name":"Department of Dermatology UCONN Health Center  Farmington Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Rabinovitz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Oliviero","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Miami Miller School of Medicine  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Scope","sequence":"additional","affiliation":[{"name":"Sheba Medical Center and Sackler Faculty of Medicine, Medical Screening Institute Tel Aviv 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