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Although immunological therapies such as T\u2010VEC offer therapeutic promise, they carry a risk of immune\u2010related adverse events (irAEs), the full spectrum of which is incompletely understood. We report a 63\u2010year\u2010old previously healthy man with cutaneous melanoma of the right ankle and progressive right lower extremity in\u2010transit metastases despite systemic therapy with immunomodulatory and molecularly targeted treatments. T\u2010VEC treatment resulted in a complete pathologic response on scouting biopsies. Biopsy of the right lateral calf showed lobular and septal panniculitis with lymphoplasmacytic infiltrate and lipophages. Gomori methenamine silver (GMS) stain and acid\u2010fast bacilli (AFB) stains were negative, and no polarizable foreign material was noted. T\u2010VEC was discontinued due to complete pathologic response and, in part, concern for development of irAEs including this panniculitis and an early concomitant autoimmune colitis. This case highlights a previously unreported irAE with this novel treatment for advanced cases of melanoma.<\/jats:p>","DOI":"10.1111\/cup.13332","type":"journal-article","created":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T06:29:01Z","timestamp":1532759341000},"page":"864-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Panniculitis in a patient with pathologic complete response to talimogene laherparepvec treatment for recurrent, in\u2010transit melanoma"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6693-594X","authenticated-orcid":false,"given":"Thomas H.","family":"Long","sequence":"first","affiliation":[{"name":"Department of Pathology University of Washington  Seattle WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-5330","authenticated-orcid":false,"given":"Michi 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