{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:01:49Z","timestamp":1784779309825,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Solid carcinoma is a poorly characterized malignant apocrine neoplasm as only 16 cases have been published.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize its clinical, histopathological, and immunohistochemical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compiled 14 cases of solid carcinoma and clinical information were updated. Hematoxylin and eosin slides were reviewed and we stained all the cases for CEA, EMA, SMA, PHLDA\u20101, BerP4, nestin, p53, p63, p75, CK5\/6, CK7 and some with remaining material for CK14, 15, CK10, CK19, S100, CD117, and CAM5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the lesions were located on the scalp. Histopathologically, all the cases were characterized by solid aggregates of neoplastic epithelial cells without nuclear atypia or mitotic figures involving all the dermis. All the cases presented perineural infiltration and most of them had cornified cystic structures. CK5\/6 and p63 were positive. CEA and EMA underlined the scarce ducts. Ki67 was lower than 1%. BerEP4 and PHLDA\u20101 were negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Solid carcinoma is a solid variant of MAC affecting the scalp more frequently than classic MAC, mostly in old males and showing variable\u2010sized nests involving the entire dermis and composed by poroid, clear\u2010cells, or a mixture of both. It is positive for p63 and CK5\/6 and negative for BerEP4 and PHLDA\u20101. Staining features with CK19 and PHLDA1 differ from classic MAC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13351","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T04:28:26Z","timestamp":1536208106000},"page":"897-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Solid carcinoma is a variant of microcystic adnexal carcinoma: A 14\u2010case series"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1187-1341","authenticated-orcid":false,"given":"Mar","family":"Llamas\u2010Velasco","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario de la Princesa  Madrid Spain"},{"name":"Fundaci\u00f3n de Investigaci\u00f3n Sanitaria (IIS\u2010IP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosmar Carolina","family":"P\u00e9rez\u2010G\u00f3nzalez","sequence":"additional","affiliation":[{"name":"Pathology Department Fundaci\u00f3n Jim\u00e9nez Diaz  Madrid Spain"},{"name":"Head of the Pathology Department Dermatopathologist, Centro M\u00e9dico Voth  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Bosch\u2010Pr\u00edncep","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital de Tortosa Verge de la Cinta  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Teresa","family":"Fern\u00e1ndez\u2010Figueras","sequence":"additional","affiliation":[{"name":"Head of Pathology Department Hospital Universitario General de Catalunya\u2010Grupo Quir\u00f3nsalud  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno","family":"R\u00fctten","sequence":"additional","affiliation":[{"name":"Dermatologist and Dermatopathologist Friedrichshafen Dermatopathologie  Friedrichshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"387","volume-title":"Neoplasms with Eccrine Differentiation","author":"Abenoza A","year":"1990"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(75)90338-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(76)90317-0"},{"key":"e_1_2_7_5_1","volume-title":"Neoplasms with Apocrine Differentiation","author":"Requena L","year":"1998"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000037"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00804.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02881.x"},{"key":"e_1_2_7_9_1","first-page":"1","volume-title":"Adnexal Tumors","author":"Kazakov D","year":"2012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2006.00710.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31826281f2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200606000-00003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2012.01876.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12085"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1989.tb03626.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70053-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70228-L"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1998.tb04272.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.120.8.1076"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198706000-00008"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200002000-00012"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198506000-00004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/archderm.1990.01670260059011","article-title":"Microcystic adnexal carcinoma. 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