{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:12:40Z","timestamp":1792138360203,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Cutaneous granulomas without detectable infectious etiology rarely occur in children and adults with primary immunodeficiency disorders. These cutaneous granulomas are primarily seen in combined variable immunodeficiency, ataxia\u2010telangiectasia, and severe combined immunodeficiency (SCID) and can emulate the reaction patterns seen in sarcoidosis and granuloma annulare. To date, the literature has described only six cases of non\u2010infectious cutaneous granulomas in SCID. We report an unusual case of cutaneous granuloma, mimicking a sarcoma, in a 40\u2010year old male with recombinase activating gene 1\u2010deficient SCID, who presented with a slow\u2010growing globus mass over the lateral aspect of the right elbow. There was heterogeneous enhancement on MRI, which was concerning for neoplasm but no malignancy was found on frozen or permanent sections. GMS, PAS with diastase, and AFB stains, as well as microbiology cultures, were negative. An AE1\/AE3 stain was negative and a CD163 stain highlighted histiocytes. No infectious etiology was identified and histopathology revealed palisaded granulomatous dermatitis, most closely resembling a rheumatoid nodule. Although cutaneous manifestations have been reported in nearly half of primary immunodeficiency disorder cases, non\u2010infectious cutaneous granulomas are exceedingly rare in SCID. To our knowledge, this is the first case report of cutaneous palisaded granulomatous dermatitis mimicking a rheumatoid nodule in a major joint.<\/jats:p>","DOI":"10.1111\/cup.13355","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T02:34:32Z","timestamp":1536633272000},"page":"940-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rheumatoid\u2010nodule\u2010like cutaneous granuloma associated with recombinase activating gene 1\u2010deficient severe combined immunodeficiency: A rare case"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-1219","authenticated-orcid":false,"given":"Sandra A.","family":"Van Horn","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Services Walter Reed National Military Medical Center  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Services Walter Reed National Military Medical Center  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Childs","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Services Walter Reed National Military Medical Center  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12765"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.01.013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3283623b9f"},{"key":"e_1_2_5_5_1","first-page":"301","volume-title":"McKee's Pathology of the Skin with Clinical Correlations","author":"Calonje E","year":"2011"},{"key":"e_1_2_5_6_1","first-page":"1171","volume-title":"Kelley and Firestein's Textbook of Rheumatology E\u2010Book","author":"Firestein GS","year":"2016"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-009-8136-z"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.09.008"},{"key":"e_1_2_5_10_1","volume-title":"Weedon's Skin Pathology E\u2010Book","author":"Patterson JW","year":"2014"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80269-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-60327-838-6","volume-title":"Inflammatory Dermatopathology","author":"Billings SD","year":"2011"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.5858\/133.5.814"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06619.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00854.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073966"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000112"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.10.010"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.13355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.13355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T03:58:03Z","timestamp":1694923083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.13355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/cup.13355"],"URL":"https:\/\/doi.org\/10.1111\/cup.13355","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"2018-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}