{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:51:51Z","timestamp":1773312711822,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTL) as strictly defined by World Health Organization\u2010European Organization for Research and Treatment of Cancer classification is a rare cytotoxic \u03b1\/\u03b2 T\u2010cell lymphoma, characterized by primary involvement of subcutaneous tissue mimicking panniculitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the clinicopathologic, immunophenotypic, and molecular features of SPTL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 10\u2010year retrospective study of 18 patients diagnosed with SPTL was thoroughly reviewed according to clinicopathology, immunophenotype, and T\u2010cell receptor (TCR) gene rearrangement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 18 patients, 16 patients were definitely diagnosed with SPTL. The median age was 26\u2009years (ranged 14\u201053\u2009years) with female predominance. Most patients presented with prolonged fever and subcutaneous nodules and\/or plaques, usually located on lower extremities. 37.5% of patients had hemophagocytic syndrome. The main histopathology was lobular panniculitis with rimming of atypical lymphocytes highlighted by CD3+, CD8+, Beta\u2010F1+, granzyme B+, and Ki\u201067 (50%\u201090%). Monoclonal TCR gene rearrangement was found in 50% of patients and upper extremities involvement indicated a poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The correlation between clinicopathologic and immunophenotypic study is the most helpful method to give a precise diagnosis of SPTL. Rimming of CD8+ atypical lymphocytes highlighted by high Ki\u201067 index is highly specific for the diagnosis of SPTL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13377","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:37:08Z","timestamp":1540280228000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinicopathologic, immunophenotypic, and molecular analysis of subcutaneous panniculitis\u2010like T\u2010cell lymphoma: A retrospective study in a tertiary care center"],"prefix":"10.1111","volume":"46","author":[{"given":"Suthinee","family":"Rutnin","sequence":"first","affiliation":[{"name":"Division of Dermatology, Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saneerat","family":"Porntharukcharoen","sequence":"additional","affiliation":[{"name":"Division of 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