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We report a diagnostically difficult case of MEBN with lymph node metastases, in which single nucleotide polymorphism array and fluorescence in situ hybridization were used to arrive at the correct diagnosis. It was also analyzed by the recently\u2010introduced proprietary 23\u2010gene expression signature test. To the best of our knowledge, this is the second reported case of MEBN analyzed by the 23\u2010gene expression signature, which provided a false\u2010negative result. More studies are needed to assess the sensitivity and specificity of this test in various melanocytic proliferations.<\/jats:p>","DOI":"10.1111\/cup.13400","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T02:28:49Z","timestamp":1543804129000},"page":"226-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A diagnostically\u2010challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23\u2010gene expression signature (myPath melanoma)"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-2321","authenticated-orcid":false,"given":"Stephanie A.","family":"Castillo","sequence":"first","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9334-9054","authenticated-orcid":false,"given":"Anh K.","family":"Pham","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Surgery Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea T.","family":"Barton","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire"},{"name":"Section of Dermatology, Department of Surgery Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel A.","family":"Lefferts","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire"},{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire"},{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Bridge","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center  Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Linos","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New Hampshire"},{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.153"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181573aaf"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf7fa0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000568"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000165527.01816.d1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2017.05.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.23"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01667.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a92cbc"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0087-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.84"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12475"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0958"},{"key":"e_1_2_5_15_1","unstructured":"Myriad Genetic Laboratories Inc.(2017).Myriad myPath\u00ae Melanoma Technical Specifications.https:\/\/myriad-library.s3.amazonaws.com\/technical-specifications\/myPath_Melanoma_Tech_Specs.pdf. 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