{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:56:38Z","timestamp":1785783398923,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:00:00Z","timestamp":1548892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Atypical spiradenoma and spiradenocarcinoma present a diagnostic challenge. We aim to assess the significance of certain histologic features, which may facilitate diagnosis of these tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A natural language search for cases of \u201catypical spiradenoma\u201d and \u201cspiradenocarcinoma\u201d diagnosed between 2009 and 2018 was performed. Original slides were retrieved and a subset of cases (n = 5) were stained for Ki\u201067, p53, carcinoembryonic antigen (CEA), and S100. All cases (n = 7) were assessed for overall architecture, atypical mitotic figures, abnormal cytology, necrosis, ductal proliferation, dilated vessels, and loss of dual cell population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All our cases showed an abrupt transition from benign to malignant morphology, nuclear atypia, atypical mitotic figures, and a monomorphic loss of the dual cell population (7\/7; 100%). The majority also had dilated vessels (6\/7; 85.7%), and ductal dilation or proliferation (5\/7; 71.4%). Fewer cases showed tumor encapsulation (3\/7; 43%), massive necrosis (3\/7; 43%), and focal cellular necrosis (1\/7; 14%). All cases showed a relatively increased Ki\u201067 proliferation index at the transitional interface (5\/5; 100%). Almost all cases stained positively for p53 (4\/5; 80%). Malignant areas of tumor or at the transitional interface showed more intense S100 staining (3\/5; 60%). All cases were negative for CEA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Histologic features that strongly favor atypical spiradenoma or spiradenocarcinoma include abrupt transition to malignant foci, atypical mitotic figures, and monomorphic loss of the dual cell population. Ki\u201067, p53, and S100 may help delineate areas of atypical or malignant transformation in spiradenomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13408","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T09:39:10Z","timestamp":1545903550000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Histological findings and pathologic diagnosis of spiradenocarcinoma: A case series and review of the literature"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-0548","authenticated-orcid":false,"given":"Amy","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology State University of New York Downstate Medical Center  Brooklyn New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikki S.","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Pathology 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