{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:12:53Z","timestamp":1785683573110,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Intravascular large B\u2010cell lymphoma (IVLBCL) is one of the rarest B\u2010cell non\u2010Hodgkin lymphomas (NHL), with an aggressive clinical behavior and a poor prognosis; in fact, its treatment is still an unmet clinical need, with a 3\u2010year overall survival (OS) rate of 60% to 81%, and a central nervous system relapse rate of 25%. It usually presents as a widespread disease at diagnosis, with multi\u2010organ involvement. Previously considered as a diffuse large B\u2010cell lymphoma variant, it now represents a different extranodal large B\u2010cell lymphoma entity in the last WHO Classification of tumors of hematopoietic and lymphoid tissues. We hereby describe the case of an 84\u2010year\u2010old Italian woman with an IVLBCL, cutaneous variant, who suffered from early relapse after R\u2010COMP chemotherapy regimen, and was therefore treated with a palliative metronomic chemotherapy. Interestingly, neoplastic cells showed CD30 expression at relapse. CD30 positivity has never been reported in this disease so far, and its expression is known to be involved in NF\u2010kB activation. CD30 expression may be further studied as for prognostic and therapeutic significance; in fact, new therapeutic strategies, such as antibody\u2010drug conjugate targeting CD30, are now available.<\/jats:p>","DOI":"10.1111\/cup.13446","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T07:57:32Z","timestamp":1550563052000},"page":"447-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["CD30 expression in a case of intravascular large B\u2010cell lymphoma, cutaneous variant"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-1457","authenticated-orcid":false,"given":"Matteo","family":"Provasi","sequence":"first","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"Dipartimento di Dermatologia, Fondazione IRCCS Ca\u2019 Granda \u2013 Ospedale 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