{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:16:34Z","timestamp":1791951394328,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Angioimmunoblastic T\u2010cell lymphoma (AITL) is a systemic peripheral T\u2010cell lymphoma with a follicular helper T\u2010cell (T<jats:sub>FH<\/jats:sub>) immunophenotype that frequently involves the skin. However, the histopathology of cutaneous involvement by AITL has not been fully established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the clinicopathological features of 19 patients seen at our institution with AITL involving the skin. Pan\u2010T\u2010cell and T<jats:sub>FH<\/jats:sub> marker expression was evaluated by immunohistochemistry. Epstein\u2010Barr virus (EBV) was detected using in situ hybridization (ISH) for Epstein\u2010Barr virus\u2010encoded small RNA (EBER). T\u2010cell receptor (TCR) gene rearrangement was evaluated by PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AITL affected both trunk and extremities in 15\/19 cases (79%). Perivascular infiltration by small and\/or medium\u2010sized lymphocytes was seen in 18\/19 (95%). Granulomatous inflammation was identified in 4\/19 (21%). Aberrant loss of CD2, CD5, or CD7 was identified in 1\/18 (6%), 2\/18 (11%), or 7\/19 (37%) cases, respectively. Seventeen of eighteen evaluable cases (95%) expressed 2 to 3 T<jats:sub>FH<\/jats:sub> markers: PD\u20101 in 19\/19 (100%), BCL6 in 94% (17\/18), and CD10 in 37% (7\/19). EBV\u2010positive cells were detected in 3\/18 (17%) with varying density. Clonal TCR gene rearrangement was identified in 9\/11 (82%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cutaneous involvement by AITL shows relatively non\u2010specific histopathological features. However, an immunohistochemical panel including T<jats:sub>FH<\/jats:sub> markers and EBER ISH is useful in differential diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.13475","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T06:47:03Z","timestamp":1555138023000},"page":"637-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Cutaneous lesions of angioimmunoblastic T\u2010cell lymphoma: Clinical, pathological, and immunophenotypic features"],"prefix":"10.1111","volume":"46","author":[{"given":"Naoki","family":"Oishi","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota"},{"name":"Department of Pathology University of Yamanashi  Yamanashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Sartori\u2010Valinotti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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